Detailed information of TA system TA236119

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1959703..1960241
• Replicon: chromosome
• Accession: NZ_CP092447
• Organism: Staphylococcus aureus strain SYN

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: LXM97_RS09415
• Protein ID: WP_031836919.1
• Coordinates: 1959703..1960029 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: C5QLS5
• Locus tag: LXM97_RS09420
• Protein ID: WP_001058489.1
• Coordinates: 1960032..1960241 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXM97_RS09395 (LXM97_09395)	1955706..1956347	-	642	WP_076692332.1	pathogenicity island protein	-
LXM97_RS09400 (LXM97_09400)	1956344..1956724	-	381	WP_000356927.1	hypothetical protein	-
LXM97_RS09405 (LXM97_09405)	1957054..1958754	-	1701	WP_000447470.1	DUF927 domain-containing protein	-
LXM97_RS09410 (LXM97_09410)	1958768..1959637	-	870	WP_001002698.1	primase alpha helix C-terminal domain-containing protein	-
LXM97_RS09415 (LXM97_09415)	1959703..1960029	-	327	WP_031836919.1	DUF1474 family protein	Toxin
LXM97_RS09420 (LXM97_09420)	1960032..1960241	-	210	WP_001058489.1	hypothetical protein	Antitoxin
LXM97_RS09425 (LXM97_09425)	1960234..1960380	-	147	WP_000784885.1	hypothetical protein	-
LXM97_RS09430 (LXM97_09430)	1960377..1960694	-	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
LXM97_RS09435 (LXM97_09435)	1960699..1960917	-	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
LXM97_RS09440 (LXM97_09440)	1961090..1961764	+	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
LXM97_RS09445 (LXM97_09445)	1961778..1962950	+	1173	WP_000179346.1	tyrosine-type recombinase/integrase	-
LXM97_RS09450 (LXM97_09450)	1963019..1964635	-	1617	WP_000240638.1	chaperonin GroEL	-
LXM97_RS09455 (LXM97_09455)	1964711..1964995	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	1948384..1964995	16611

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13002.40 Da
• Isoelectric Point: 4.3444

>T236119 WP_031836919.1 NZ_CP092447:c1960029-1959703 [Staphylococcus aureus]
MDWEIKSLFSDLKLLKDSFEDLKDNHGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSDVSLATESDDAQKLKITE

Nucleotide

• Length: 327 bp

>T236119 NZ_LR135352:47853-48203 [Enterococcus faecium]
ATGGTGAGAAAACCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACACGAACAGACAGGTAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCGGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTACAACTA
GAAACTATCCGCTATATGTAAATATAAACTCAGAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCGCATGATAGTTTAGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTTTTTCAAAAAGTAAGCAAATAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8225.24 Da
• Isoelectric Point: 4.2820

>AT236119 WP_001058489.1 NZ_CP092447:c1960241-1960032 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT236119 NZ_LR135352:47596-47859 [Enterococcus faecium]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGCCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGTCAGAAGCGGCTAATTATCGAAGCGGCTAATATAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGATGAAAGAAATCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A853V601