Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1844862..1845638 Replicon chromosome
Accession NZ_CP092447
Organism Staphylococcus aureus strain SYN

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag LXM97_RS08715 Protein ID WP_000031108.1
Coordinates 1844862..1845014 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag LXM97_RS08720 Protein ID WP_001251218.1
Coordinates 1845039..1845638 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXM97_RS08700 (LXM97_08700) 1840937..1841758 + 822 WP_000669384.1 RluA family pseudouridine synthase -
LXM97_RS08705 (LXM97_08705) 1842223..1843608 - 1386 WP_000116233.1 class II fumarate hydratase -
LXM97_RS08710 (LXM97_08710) 1843804..1844199 - 396 WP_000901022.1 hypothetical protein -
LXM97_RS08715 (LXM97_08715) 1844862..1845014 - 153 WP_000031108.1 SAS053 family protein Toxin
LXM97_RS08720 (LXM97_08720) 1845039..1845638 - 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
LXM97_RS08725 (LXM97_08725) 1845797..1846267 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LXM97_RS08730 (LXM97_08730) 1846272..1847399 - 1128 WP_000379977.1 tRNA epoxyqueuosine(34) reductase QueG -
LXM97_RS08735 (LXM97_08735) 1847550..1848272 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
LXM97_RS08740 (LXM97_08740) 1848265..1849722 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hysA / scn / chp 1775918..1848278 72360


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T236118 WP_000031108.1 NZ_CP092447:c1845014-1844862 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T236118 NZ_LR135351:c2456996-2456655 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT236118 WP_001251218.1 NZ_CP092447:c1845638-1845039 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT236118 NZ_LR135351:c2457226-2456996 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References