Detailed information of TA system TA236117

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 816369..816846
• Replicon: chromosome
• Accession: NZ_CP092447
• Organism: Staphylococcus aureus strain SYN

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: LXM97_RS03805
• Protein ID: WP_000052076.1
• Coordinates: 816369..816557 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: LXM97_RS03810
• Protein ID: WP_001059690.1
• Coordinates: 816586..816846 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXM97_RS03775 (LXM97_03775)	812407..812877	+	471	WP_000824462.1	hypothetical protein	-
LXM97_RS03780 (LXM97_03780)	813218..813904	+	687	WP_001823812.1	thermonuclease family protein	-
LXM97_RS03785 (LXM97_03785)	814261..814461	+	201	WP_001059082.1	cold-shock protein	-
LXM97_RS03790 (LXM97_03790)	814960..815178	-	219	WP_000005888.1	hypothetical protein	-
LXM97_RS03795 (LXM97_03795)	815240..815524	-	285	WP_001004397.1	hypothetical protein	-
LXM97_RS03800 (LXM97_03800)	815612..816181	-	570	WP_001106657.1	lipoprotein N-acylation protein LnsA	-
LXM97_RS03805 (LXM97_03805)	816369..816557	-	189	WP_000052076.1	hypothetical protein	Toxin
LXM97_RS03810 (LXM97_03810)	816586..816846	-	261	WP_001059690.1	hypothetical protein	Antitoxin
LXM97_RS03815 (LXM97_03815)	817018..818310	+	1293	WP_000777467.1	IS21 family transposase	-
LXM97_RS03820 (LXM97_03820)	818303..819064	+	762	WP_001066124.1	IS21-like element helper ATPase IstB	-
LXM97_RS03825 (LXM97_03825)	819393..819596	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
LXM97_RS03830 (LXM97_03830)	819593..819829	-	237	WP_000368687.1	hypothetical protein	-
LXM97_RS03835 (LXM97_03835)	820053..820634	+	582	WP_001140697.1	histidine phosphatase family protein	-
LXM97_RS03840 (LXM97_03840)	820707..821324	-	618	WP_000255554.1	LysE/ArgO family amino acid transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	clpP / vWbp	783286..829619	46333
	-	flank	IS/Tn	-	-	818300..819064	764

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (22-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (5-69)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T236117 WP_000052076.1 NZ_CP092447:c816557-816369 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T236117 NZ_LR135351:200184-200450 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT236117 WP_001059690.1 NZ_CP092447:c816846-816586 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT236117 NZ_LR135351:199921-200184 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56