Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4706788..4707404 Replicon chromosome
Accession NZ_CP092442
Organism Citrobacter portucalensis strain Sb-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I9P40_RS22345 Protein ID WP_020996118.1
Coordinates 4706788..4707162 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I9P40_RS22350 Protein ID WP_020996119.1
Coordinates 4707162..4707404 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9P40_RS22330 (I9P40_09675) 4704291..4705193 + 903 WP_003825273.1 formate dehydrogenase O subunit beta -
I9P40_RS22335 (I9P40_09670) 4705190..4705825 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
I9P40_RS22340 (I9P40_09665) 4705822..4706751 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
I9P40_RS22345 (I9P40_09660) 4706788..4707162 - 375 WP_020996118.1 type II toxin-antitoxin system VapC family toxin Toxin
I9P40_RS22350 (I9P40_09655) 4707162..4707404 - 243 WP_020996119.1 CopG family transcriptional regulator Antitoxin
I9P40_RS22355 (I9P40_09650) 4707610..4708539 + 930 WP_198802932.1 alpha/beta hydrolase -
I9P40_RS22360 (I9P40_09645) 4708624..4708935 + 312 WP_048215202.1 type II toxin-antitoxin system HigB family toxin -
I9P40_RS22365 (I9P40_09640) 4708932..4709378 + 447 WP_048215203.1 helix-turn-helix domain-containing protein -
I9P40_RS22370 (I9P40_09635) 4709396..4710337 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
I9P40_RS22375 (I9P40_09630) 4710382..4710819 - 438 WP_003825289.1 D-aminoacyl-tRNA deacylase -
I9P40_RS22380 (I9P40_09625) 4710816..4711688 - 873 WP_008786998.1 virulence factor BrkB family protein -
I9P40_RS22385 (I9P40_09620) 4711682..4712281 - 600 WP_103285939.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13648.86 Da        Isoelectric Point: 9.6927

>T236113 WP_020996118.1 NZ_CP092442:c4707162-4706788 [Citrobacter portucalensis]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEHGMKLPDAIILATAQIHRLTLVTRNTKDFAGISGVVTPYTL

Download         Length: 375 bp

>T236113 NZ_LR135342:18722-19585 [Enterococcus faecium]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCGAATCGCATGACAGAAGCACTTATTAGCCGTTTAAG
CGATCAAGGCTATAATTTAGTGATTGAAGGAACAGGACGAACAACAGACGTTCCCATTCAAACAGCCACAATGCTTCAAT
CTAAAGGTTATGAAACAAAAATATACGTCATGGCAGTACCGAAAATTGAATCATACTTAGGAACGATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCTAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCTACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9479.80 Da        Isoelectric Point: 4.3437

>AT236113 WP_020996119.1 NZ_CP092442:c4707404-4707162 [Citrobacter portucalensis]
MMVGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp

>AT236113 NZ_LR135342:18448-18720 [Enterococcus faecium]
ATGGCAGTTACGTATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAA
TTATGTTTTGAATCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References