Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4546511..4547099 Replicon chromosome
Accession NZ_CP092442
Organism Citrobacter portucalensis strain Sb-2

Toxin (Protein)


Gene name PumA Uniprot ID A0A5B0T4T9
Locus tag I9P40_RS21630 Protein ID WP_032942059.1
Coordinates 4546511..4546828 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A5B0STC7
Locus tag I9P40_RS21635 Protein ID WP_032942057.1
Coordinates 4546821..4547099 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9P40_RS21605 (I9P40_10400) 4542279..4543103 + 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
I9P40_RS21610 (I9P40_10395) 4543172..4544395 + 1224 WP_032942071.1 L-sorbose 1-phosphate reductase -
I9P40_RS21615 (I9P40_10390) 4544397..4545209 + 813 WP_198803117.1 shikimate 5-dehydrogenase -
I9P40_RS21620 (I9P40_10385) 4545259..4545420 - 162 WP_233097552.1 hypothetical protein -
I9P40_RS21625 (I9P40_10380) 4545696..4546247 + 552 WP_008786891.1 AAA family ATPase -
I9P40_RS21630 (I9P40_10375) 4546511..4546828 + 318 WP_032942059.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I9P40_RS21635 (I9P40_10370) 4546821..4547099 + 279 WP_032942057.1 putative addiction module antidote protein Antitoxin
I9P40_RS21640 (I9P40_10365) 4547210..4547899 + 690 WP_032942056.1 dipeptidase PepE -
I9P40_RS21645 (I9P40_10360) 4547965..4549596 - 1632 WP_048236377.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(3-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11993.00 Da        Isoelectric Point: 9.6790

>T236112 WP_032942059.1 NZ_CP092442:4546511-4546828 [Citrobacter portucalensis]
IMEILQTMVFRRWEQNLRDRRAKTLIATRLFRLANGLAGDVKPVGEGVSEMRISYGPGYRIYFKQQGCRIIILLCGGDKS
SQANDITLAKMLARTLDSQEIFCHE

Download         Length: 318 bp

>T236112 NZ_LR135340:c198376-198026 [Enterococcus faecium]
ATGGTGAGAAAACCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACACGAACAGACAGGTAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCGGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTACAACTA
GAAACTATCCGCTATATGTAAATATAAACTCAGAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCGCATGATAGTTTAGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTTTTTCAAAAAGTAAGCAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9872.45 Da        Isoelectric Point: 5.8233

>AT236112 WP_032942057.1 NZ_CP092442:4546821-4547099 [Citrobacter portucalensis]
MNKLTHYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKVLGIELTLKK

Download         Length: 279 bp

>AT236112 NZ_LR135340:c198633-198370 [Enterococcus faecium]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGCCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGTCAGAAGCGGCTAATTATCGAAGCGGCTAATATAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGATGAAAGAAATCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B0T4T9

Antitoxin

Source ID Structure
AlphaFold DB A0A5B0STC7

References