Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2472977..2473713 Replicon chromosome
Accession NZ_CP092442
Organism Citrobacter portucalensis strain Sb-2

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag I9P40_RS11705 Protein ID WP_198802197.1
Coordinates 2473231..2473713 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag I9P40_RS11700 Protein ID WP_008784769.1
Coordinates 2472977..2473243 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9P40_RS11680 (I9P40_20320) 2468029..2469216 + 1188 WP_048235374.1 outer membrane protein transport protein -
I9P40_RS11685 (I9P40_20315) 2469454..2470083 + 630 WP_008784772.1 winged helix-turn-helix transcriptional regulator -
I9P40_RS11690 (I9P40_20310) 2470200..2470586 - 387 WP_008784771.1 hypothetical protein -
I9P40_RS11695 (I9P40_20305) 2470841..2472823 + 1983 WP_198802199.1 alkyl sulfatase dimerization domain-containing protein -
I9P40_RS11700 (I9P40_20300) 2472977..2473243 + 267 WP_008784769.1 DUF1778 domain-containing protein Antitoxin
I9P40_RS11705 (I9P40_20295) 2473231..2473713 + 483 WP_198802197.1 GNAT family N-acetyltransferase Toxin
I9P40_RS11710 (I9P40_20290) 2474010..2475197 - 1188 WP_060682211.1 outer membrane protein transport protein -
I9P40_RS11715 (I9P40_20285) 2475290..2476405 - 1116 WP_079934033.1 DUF4056 domain-containing protein -
I9P40_RS11720 (I9P40_20280) 2476406..2477536 - 1131 WP_048235381.1 BamA/TamA family outer membrane protein -
I9P40_RS11725 (I9P40_20275) 2477536..2478474 - 939 WP_008784763.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17613.45 Da        Isoelectric Point: 9.8713

>T236109 WP_198802197.1 NZ_CP092442:2473231-2473713 [Citrobacter portucalensis]
VGFVTAPEPLTHIHQLAEFVSGEIVLDDWLKQKGLKNQALGAARTFVVCKTDTRKVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSVRGKGLGADLLHDAVLRCYKVAENIGVRAVMVHALTDEAKRFYLHHGFKASQLQERTLFLRLS

Download         Length: 483 bp

>T236109 NZ_LR135334:8412-8669 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10159.65 Da        Isoelectric Point: 4.6558

>AT236109 WP_008784769.1 NZ_CP092442:2472977-2473243 [Citrobacter portucalensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIEMLDAPVAEDPAIRKLL
ARKPQWDL

Download         Length: 267 bp

>AT236109 NZ_LR135334:8150-8419 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References