Detailed information of TA system TA023610

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1391292..1391851
• Replicon: chromosome
• Accession: NC_012207
• Organism: Mycobacterium bovis BCG str. Tokyo 172

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: JTY_RS06625
• Protein ID: WP_003898789.1
• Coordinates: 1391292..1391585 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: JTY_RS06630
• Protein ID: WP_003406322.1
• Coordinates: 1391582..1391851 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JTY_RS06600	1386885..1387145	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
JTY_RS06605	1387142..1387573	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
JTY_RS06610	1387596..1389284	-	1689	WP_003910308.1	PE family protein	-
JTY_RS06615	1389464..1390324	+	861	WP_003406306.1	hypothetical protein	-
JTY_RS06620	1390405..1391235	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
JTY_RS06625	1391292..1391585	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
JTY_RS06630	1391582..1391851	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JTY_RS06635	1391964..1395659	-	3696	WP_010950509.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
JTY_RS06640	1395801..1396589	-	789	WP_010950510.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T23610 WP_003898789.1 NC_012207:c1391585-1391292 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T23610 NC_012207:c1391585-1391292 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT23610 WP_003406322.1 NC_012207:c1391851-1391582 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT23610 NC_012207:c1391851-1391582 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2