Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 784311..784965 Replicon chromosome
Accession NZ_CP092442
Organism Citrobacter portucalensis strain Sb-2

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag I9P40_RS03775 Protein ID WP_003825515.1
Coordinates 784558..784965 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag I9P40_RS03770 Protein ID WP_003825514.1
Coordinates 784311..784577 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9P40_RS03745 (I9P40_05050) 779466..780899 - 1434 WP_198801773.1 6-phospho-beta-glucosidase BglA -
I9P40_RS03750 (I9P40_05045) 781020..781748 - 729 WP_008785744.1 MurR/RpiR family transcriptional regulator -
I9P40_RS03755 (I9P40_05040) 781801..782112 + 312 WP_048225466.1 N(4)-acetylcytidine aminohydrolase -
I9P40_RS03760 (I9P40_05035) 782276..782938 + 663 WP_071445549.1 hemolysin III family protein -
I9P40_RS03765 (I9P40_05030) 783070..784053 - 984 WP_048236721.1 tRNA-modifying protein YgfZ -
I9P40_RS03770 (I9P40_05025) 784311..784577 + 267 WP_003825514.1 FAD assembly factor SdhE Antitoxin
I9P40_RS03775 (I9P40_05020) 784558..784965 + 408 WP_003825515.1 protein YgfX Toxin
I9P40_RS03780 (I9P40_05015) 785067..785588 - 522 WP_003026933.1 flavodoxin FldB -
I9P40_RS03785 (I9P40_05010) 785702..786598 + 897 WP_003825519.1 site-specific tyrosine recombinase XerD -
I9P40_RS03790 (I9P40_05005) 786622..787335 + 714 WP_048225463.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I9P40_RS03795 (I9P40_05000) 787341..789074 + 1734 WP_198801774.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15882.76 Da        Isoelectric Point: 11.3523

>T236098 WP_003825515.1 NZ_CP092442:784558-784965 [Citrobacter portucalensis]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQG

Download         Length: 408 bp

>T236098 NZ_LR135317:486795-487136 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10615.14 Da        Isoelectric Point: 5.1700

>AT236098 WP_003825514.1 NZ_CP092442:784311-784577 [Citrobacter portucalensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADEQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT236098 NZ_LR135317:486565-486795 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References