Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 196881..197566 Replicon plasmid pRSpK102b
Accession NZ_CP092438
Organism Rhizobium sp. K102

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MHI61_RS31555 Protein ID WP_239793726.1
Coordinates 196881..197303 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MHI61_RS31560 Protein ID WP_239793727.1
Coordinates 197300..197566 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MHI61_RS31535 (MHI61_31540) 192840..194192 + 1353 WP_239793723.1 LLM class flavin-dependent oxidoreductase -
MHI61_RS31540 (MHI61_31545) 194203..195054 + 852 WP_239793724.1 ABC transporter permease -
MHI61_RS31545 (MHI61_31550) 195090..196073 + 984 WP_239793725.1 ABC transporter substrate-binding protein -
MHI61_RS31550 (MHI61_31555) 196083..196852 + 770 Protein_191 ABC transporter ATP-binding protein -
MHI61_RS31555 (MHI61_31560) 196881..197303 - 423 WP_239793726.1 type II toxin-antitoxin system VapC family toxin Toxin
MHI61_RS31560 (MHI61_31565) 197300..197566 - 267 WP_239793727.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MHI61_RS31565 (MHI61_31570) 197637..199451 - 1815 WP_239793728.1 chloride channel protein -
MHI61_RS31570 (MHI61_31575) 199657..200094 + 438 WP_239793729.1 helix-turn-helix domain-containing protein -
MHI61_RS31575 (MHI61_31580) 200119..200907 - 789 WP_239793730.1 ABC transporter ATP-binding protein -
MHI61_RS31580 (MHI61_31585) 200904..201956 - 1053 WP_239793731.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..405132 405132


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-63)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15823.14 Da        Isoelectric Point: 5.0179

>T236094 WP_239793726.1 NZ_CP092438:c197303-196881 [Rhizobium sp. K102]
VRLLLDTNVLSEVTRPNPDMRVLAWLDQLDEDRSFISIVSIAEIRRGVALMDERRKRDALAEWLARELPQRFERRIIPVD
EPVASAWGDLMGRAKRSGRGLSSMDGLIAATAAAHDLTLATRNTRDFEGFGIELIDPWIV

Download         Length: 423 bp

>T236094 NZ_LR135309:26633-26983 [Enterococcus faecium]
ATGGTGAGAAAACCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACACGAACAGACAGGTAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCGGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTACAACTA
GAAACTATCCGCTATATGTAAATATAAACTCAGAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCGCATGATAGTTTAGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTTTTTCAAAAAGTAAGCAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9720.87 Da        Isoelectric Point: 5.1617

>AT236094 WP_239793727.1 NZ_CP092438:c197566-197300 [Rhizobium sp. K102]
MQPSRQGDESWTVASAKAKLSEVIERAQSAPQTITRNGKPSVVVVSAEEWQRKTARKGTLAEFLMSSPLRGADLDLERQG
DEPRDPEL

Download         Length: 267 bp

>AT236094 NZ_LR135309:26376-26639 [Enterococcus faecium]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGCCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGTCAGAAGCGGCTAATTATCGAAGCGGCTAATATAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGATGAAAGAAATCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References