Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 160015..160571 Replicon plasmid pRSpK102b
Accession NZ_CP092438
Organism Rhizobium sp. K102

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag MHI61_RS31365 Protein ID WP_239793692.1
Coordinates 160281..160571 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MHI61_RS31360 Protein ID WP_239793691.1
Coordinates 160015..160293 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MHI61_RS31340 (MHI61_31345) 155395..156282 - 888 WP_239793687.1 sugar ABC transporter permease -
MHI61_RS31345 (MHI61_31350) 156382..157614 - 1233 WP_239793688.1 ABC transporter substrate-binding protein -
MHI61_RS31350 (MHI61_31355) 157673..158626 - 954 WP_239793689.1 sugar phosphate isomerase/epimerase -
MHI61_RS31355 (MHI61_31360) 158849..159919 + 1071 WP_239793690.1 LacI family DNA-binding transcriptional regulator -
MHI61_RS31360 (MHI61_31365) 160015..160293 + 279 WP_239793691.1 CopG family ribbon-helix-helix protein Antitoxin
MHI61_RS31365 (MHI61_31370) 160281..160571 + 291 WP_239793692.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MHI61_RS31370 (MHI61_31375) 160770..161201 + 432 WP_239793693.1 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit -
MHI61_RS31375 (MHI61_31380) 161201..162595 + 1395 WP_239793694.1 acetyl-CoA carboxylase biotin carboxylase subunit -
MHI61_RS31380 (MHI61_31385) 162592..163005 + 414 WP_239793695.1 acetyl-CoA carboxylase -
MHI61_RS31385 (MHI61_31390) 163002..163709 + 708 WP_239793696.1 5-oxoprolinase subunit PxpB -
MHI61_RS31390 (MHI61_31395) 163706..164701 + 996 WP_239793697.1 biotin-dependent carboxyltransferase family protein -
MHI61_RS31395 (MHI61_31400) 164723..165490 + 768 WP_239793698.1 5-oxoprolinase subunit PxpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..405132 405132


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10955.65 Da        Isoelectric Point: 8.5684

>T236093 WP_239793692.1 NZ_CP092438:160281-160571 [Rhizobium sp. K102]
MPQVIFSPAAIRDLERLREFLRPKNPSVARRAGETILKGVSLLAAHPHMGRLIEDLPEQYREWLIDFGESGYVARYRVDG
DILTVLAVRHQKEAGF

Download         Length: 291 bp

>T236093 NZ_LR135308:c137304-137032 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACATATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10680.87 Da        Isoelectric Point: 4.9445

>AT236093 WP_239793691.1 NZ_CP092438:160015-160293 [Rhizobium sp. K102]
MASPTSLKLDDELKGRVQQLAEARRRSSHWIMREAIAQYVEREERREALRQETLDAWNEFEATGLHVTGAQVEKWLSTWG
TDDELSAPECHK

Download         Length: 279 bp

>AT236093 NZ_LR135308:c137567-137304 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTTGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References