Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 381923..382584 Replicon plasmid pRSpK102d
Accession NZ_CP092437
Organism Rhizobium sp. K102

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MHI61_RS29245 Protein ID WP_239792959.1
Coordinates 381923..382327 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MHI61_RS29250 Protein ID WP_239792960.1
Coordinates 382324..382584 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MHI61_RS29230 (MHI61_29235) 377347..378267 - 921 WP_239792957.1 hydrogen peroxide-inducible genes activator -
MHI61_RS29235 (MHI61_29240) 378412..380594 + 2183 Protein_335 catalase/peroxidase HPI -
MHI61_RS29240 (MHI61_29245) 381111..381836 + 726 WP_239792958.1 SDR family oxidoreductase -
MHI61_RS29245 (MHI61_29250) 381923..382327 - 405 WP_239792959.1 type II toxin-antitoxin system VapC family toxin Toxin
MHI61_RS29250 (MHI61_29255) 382324..382584 - 261 WP_239792960.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MHI61_RS29255 (MHI61_29260) 382668..383219 - 552 WP_239792961.1 DUF3299 domain-containing protein -
MHI61_RS29260 (MHI61_29265) 383491..383946 - 456 WP_239792962.1 SgcJ/EcaC family oxidoreductase -
MHI61_RS29265 (MHI61_29270) 384138..385262 + 1125 WP_239792963.1 sensor histidine kinase -
MHI61_RS29270 (MHI61_29275) 385259..385918 + 660 WP_239792964.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..643909 643909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(8-45)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14542.64 Da        Isoelectric Point: 4.9246

>T236092 WP_239792959.1 NZ_CP092437:c382327-381923 [Rhizobium sp. K102]
VITHLIDTNAVIALIGRKSEALLKRVVDSDEGSIGLSTVVMHELYYGAYKSAKISHNLETLRLFMADFPAVGFEREDALA
SGEIRAALAAKGTPIGPYDVLIAAQAKTRDLVLITNNVGEFRRVDGLDVEDWTA

Download         Length: 405 bp

>T236092 NZ_LR135307:553655-553996 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9818.00 Da        Isoelectric Point: 5.1351

>AT236092 WP_239792960.1 NZ_CP092437:c382584-382324 [Rhizobium sp. K102]
MPQYARVFQSGNSQAVRLPKEFRFDVDQVEVTREGDAVILRPRADPGMRWASLRSALERGLSDDFLAQGREQPEDQERPG
LQGLFK

Download         Length: 261 bp

>AT236092 NZ_LR135307:553425-553655 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References