Detailed information of TA system TA023609

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1386885..1387573
• Replicon: chromosome
• Accession: NC_012207
• Organism: Mycobacterium bovis BCG str. Tokyo 172

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: JTY_RS06605
• Protein ID: WP_003406304.1
• Coordinates: 1387142..1387573 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: JTY_RS06600
• Protein ID: WP_003406302.1
• Coordinates: 1386885..1387145 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JTY_RS06580	1382462..1383286	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
JTY_RS06585	1383291..1384472	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
JTY_RS06590	1384549..1385649	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
JTY_RS06595	1385820..1386809	+	990	WP_003406301.1	malate dehydrogenase	-
JTY_RS06600	1386885..1387145	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
JTY_RS06605	1387142..1387573	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
JTY_RS06610	1387596..1389284	-	1689	WP_003910308.1	PE family protein	-
JTY_RS06615	1389464..1390324	+	861	WP_003406306.1	hypothetical protein	-
JTY_RS06620	1390405..1391235	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
JTY_RS06625	1391292..1391585	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
JTY_RS06630	1391582..1391851	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T23609 WP_003406304.1 NC_012207:1387142-1387573 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T23609 NC_012207:1387142-1387573 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT23609 WP_003406302.1 NC_012207:1386885-1387145 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT23609 NC_012207:1386885-1387145 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6