Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 5474886..5475453 Replicon chromosome
Accession NZ_CP092431
Organism Streptomyces deccanensis strain KCTC 19241

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L3078_RS24410 Protein ID WP_239756092.1
Coordinates 5475172..5475453 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag L3078_RS24405 Protein ID WP_239756091.1
Coordinates 5474886..5475167 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3078_RS24380 (L3078_24380) 5470299..5470904 + 606 WP_239756087.1 TetR/AcrR family transcriptional regulator -
L3078_RS24385 (L3078_24385) 5470954..5472099 - 1146 WP_239760450.1 sugar ABC transporter permease -
L3078_RS24390 (L3078_24390) 5472405..5473181 - 777 WP_239756088.1 ATP-binding cassette domain-containing protein -
L3078_RS24395 (L3078_24395) 5473266..5474393 - 1128 WP_239756089.1 substrate-binding domain-containing protein -
L3078_RS24400 (L3078_24400) 5474530..5474778 + 249 WP_239756090.1 hypothetical protein -
L3078_RS24405 (L3078_24405) 5474886..5475167 + 282 WP_239756091.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L3078_RS24410 (L3078_24410) 5475172..5475453 + 282 WP_239756092.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L3078_RS24415 (L3078_24415) 5475547..5477115 + 1569 WP_239756093.1 SDR family oxidoreductase -
L3078_RS24420 (L3078_24420) 5477337..5477975 + 639 WP_239756094.1 hypothetical protein -
L3078_RS24425 (L3078_24425) 5478000..5478902 - 903 WP_239756095.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10638.33 Da        Isoelectric Point: 10.7805

>T236087 WP_239756092.1 NZ_CP092431:5475172-5475453 [Streptomyces deccanensis]
MGYVTRFTPHAQRDMLKVPRPDALRILYRLAELQKAMDAGGTESFDIKALQGHSARWRLRVGDSRVVYTVEGGQLIVWVL
AVGNRRDIYRQVP

Download         Length: 282 bp

>T236087 NZ_LR135294:c231634-231239 [Enterococcus faecium]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCGAATCGCATGACAGAAGCACTTATTAGCCGTTTAAG
CGATCAAGGCTATAATTTAGTGATTGAAGGGTTCTGTTGCAAAGTTTTAAATCTACTATCAAATAAGGTAGAATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10515.61 Da        Isoelectric Point: 4.2038

>AT236087 WP_239756091.1 NZ_CP092431:5474886-5475167 [Streptomyces deccanensis]
MSEPVIESMAEVRSHLADVIDRAHREETPTIITRRGKQEAVVIDIQEYQRLREIAENAEEAWLNQLADEAESEGTEGSVS
LEEMAALLRTHQS

Download         Length: 282 bp

>AT236087 NZ_LR135294:c231908-231636 [Enterococcus faecium]
ATGGCAGTTACGTATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAA
TTATGTTTTGAATCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References