Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2410978..2411942 Replicon chromosome
Accession NZ_CP092430
Organism Mycolicibacter virginiensis strain DSM 100883

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag MJO54_RS11595 Protein ID WP_046283182.1
Coordinates 2411364..2411942 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag MJO54_RS11590 Protein ID WP_046283183.1
Coordinates 2410978..2411367 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJO54_RS11570 (MJO54_11545) 2407195..2408796 - 1602 WP_046283186.1 FAD-binding protein -
MJO54_RS11575 (MJO54_11550) 2408985..2409830 + 846 WP_105295719.1 lytic transglycosylase domain-containing protein -
MJO54_RS11580 (MJO54_11555) 2409835..2410200 - 366 WP_064889414.1 S4 domain-containing protein -
MJO54_RS11585 (MJO54_11560) 2410213..2410815 - 603 WP_046283184.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
MJO54_RS11590 (MJO54_11565) 2410978..2411367 + 390 WP_046283183.1 hypothetical protein Antitoxin
MJO54_RS11595 (MJO54_11570) 2411364..2411942 + 579 WP_046283182.1 zeta toxin family protein Toxin
MJO54_RS11600 (MJO54_11575) 2411939..2412952 - 1014 WP_046283181.1 NADP-dependent oxidoreductase -
MJO54_RS11605 (MJO54_11580) 2413026..2413676 - 651 WP_046283180.1 maleylpyruvate isomerase family mycothiol-dependent enzyme -
MJO54_RS11610 (MJO54_11585) 2413683..2414222 - 540 WP_046283179.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
MJO54_RS11615 (MJO54_11590) 2414302..2415339 + 1038 WP_105295702.1 TIGR03617 family F420-dependent LLM class oxidoreductase -
MJO54_RS11620 (MJO54_11595) 2415350..2416237 + 888 WP_105295703.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(5-129)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 20901.09 Da        Isoelectric Point: 9.3753

>T236084 WP_046283182.1 NZ_CP092430:2411364-2411942 [Mycolicibacter virginiensis]
MRRLDLVVGPNGAGKSTFVALTLAPLLPGVPFVNADEIAKNRWPDEAAAHAYDAARLAAQTRMKLIEAGRSFIAETVFSH
ESKIELIRTADAHDYTVVLHAVLIPEALAIHRVRYRVAAGGHTVPEGKIRERYHRLWPLVAEAIGMVDVATVYENSRAAG
PKIVAQFAGGAPIGELSWPAWAPDALVTRWRA

Download         Length: 579 bp

>T236084 NZ_LR135293:494450-494791 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13768.15 Da        Isoelectric Point: 4.7881

>AT236084 WP_046283183.1 NZ_CP092430:2410978-2411367 [Mycolicibacter virginiensis]
MPEVADRVTRFAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSAQQSAARRRVEAALAGHLDTGALTAEEGVVFNAEI
SAAIEENLSHTHYGDILAERGVTTVALDDDGRIVEYRPDGTSVIVEASR

Download         Length: 390 bp

>AT236084 NZ_LR135293:494220-494450 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References