Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | unclassified/Polyketide_cyc2(toxin) |
| Location | 705810..706449 | Replicon | chromosome |
| Accession | NZ_CP092429 | ||
| Organism | Mycobacterium ulcerans strain ATCC 19423 | ||
Toxin (Protein)
| Gene name | novel[antitoxin] | Uniprot ID | - |
| Locus tag | MJO63_RS03380 | Protein ID | WP_240168794.1 |
| Coordinates | 706003..706449 (+) | Length | 149 a.a. |
Antitoxin (Protein)
| Gene name | novel[toxin] | Uniprot ID | B2HEJ8 |
| Locus tag | MJO63_RS03375 | Protein ID | WP_011738542.1 |
| Coordinates | 705810..705998 (+) | Length | 63 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MJO63_RS03355 (MJO63_03360) | 701411..702712 | + | 1302 | WP_240168791.1 | ISAs1 family transposase | - |
| MJO63_RS03360 (MJO63_03365) | 702730..702963 | - | 234 | Protein_660 | IS256 family transposase | - |
| MJO63_RS03365 (MJO63_03370) | 703020..704369 | - | 1350 | WP_240168792.1 | IS256 family transposase | - |
| MJO63_RS03370 (MJO63_03375) | 704609..705634 | + | 1026 | WP_240168793.1 | hypothetical protein | - |
| MJO63_RS03375 (MJO63_03380) | 705810..705998 | + | 189 | WP_011738542.1 | antitoxin | Antitoxin |
| MJO63_RS03380 (MJO63_03385) | 706003..706449 | + | 447 | WP_240168794.1 | SRPBCC family protein | Toxin |
| MJO63_RS03385 (MJO63_03390) | 706561..707205 | - | 645 | WP_231507106.1 | hypothetical protein | - |
| MJO63_RS03390 (MJO63_03395) | 707286..707804 | - | 519 | WP_240168795.1 | EspA/EspE family type VII secretion system effector | - |
| MJO63_RS03395 (MJO63_03400) | 707982..708755 | + | 774 | WP_011738540.1 | VOC family protein | - |
| MJO63_RS03400 (MJO63_03405) | 708826..709260 | + | 435 | WP_011738539.1 | hypothetical protein | - |
| MJO63_RS03405 (MJO63_03410) | 709266..709739 | - | 474 | WP_071498317.1 | VOC family protein | - |
| MJO63_RS03410 (MJO63_03415) | 709756..711276 | - | 1521 | WP_240168796.1 | carotenoid oxygenase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 149 a.a. Molecular weight: 15860.44 Da Isoelectric Point: 9.7664
>T236079 WP_240168794.1 NZ_CP092429:706003-706449 [Mycobacterium ulcerans]
MAKLSGSIDVPLSPDEAWMHASDLSRFKEWLTIHRVWRSTLPETLEKGAVVESIVQVKGMHNRIKWTIVRYQPPEGMTLN
GDGVGGVKVKLMAKVAAGEQGSIVSFDVHLGGPALFGPIGMVVAAALRSDINASLRNFVTVFAPPAAG
MAKLSGSIDVPLSPDEAWMHASDLSRFKEWLTIHRVWRSTLPETLEKGAVVESIVQVKGMHNRIKWTIVRYQPPEGMTLN
GDGVGGVKVKLMAKVAAGEQGSIVSFDVHLGGPALFGPIGMVVAAALRSDINASLRNFVTVFAPPAAG
Download Length: 447 bp
>T236079 NZ_LR135283:c5553-4690 [Enterococcus faecium]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTATATAACAGAGAAGGAGTAAAACTCTATTCAA
GTTTGGAAACACCTTCTATTAGTCCAAAAGAAACCTTAGAAAAAGAATTGAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTATATAACAGAGAAGGAGTAAAACTCTATTCAA
GTTTGGAAACACCTTCTATTAGTCCAAAAGAAACCTTAGAAAAAGAATTGAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA
Antitoxin
Download Length: 63 a.a. Molecular weight: 6586.35 Da Isoelectric Point: 4.7205
>AT236079 WP_011738542.1 NZ_CP092429:705810-705998 [Mycobacterium ulcerans]
MGILDKAKDLLAQNADKVETVIDKAGEFVDEKTEGKYSDTIHKVQEGAKKVAGPGAAGEQQN
MGILDKAKDLLAQNADKVETVIDKAGEFVDEKTEGKYSDTIHKVQEGAKKVAGPGAAGEQQN
Download Length: 189 bp
>AT236079 NZ_LR135283:c5827-5555 [Enterococcus faecium]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|