Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 207364..208030 Replicon plasmid unnamed1
Accession NZ_CP092424
Organism Mycobacterium lentiflavum strain ATCC 51985

Toxin (Protein)


Gene name vapC Uniprot ID A0A1X0XNF8
Locus tag MJO58_RS28420 Protein ID WP_061560252.1
Coordinates 207635..208030 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X0XN39
Locus tag MJO58_RS28415 Protein ID WP_061559440.1
Coordinates 207364..207630 (+) Length 89 a.a.

Genomic Context

MJO58_RS28415MJO58_RS28420MJO58_RS28435MJO58_RS28780MJO58_RS28400MJO58_RS28405MJO58_RS28410MJO58_RS28425MJO58_RS28430MJO58_RS28440
Location: 207364..207630 (267 bp)
Type: Antitoxin
Protein ID: WP_061559440.1
Location: 207635..208030 (396 bp)
Type: Toxin
Protein ID: WP_061560252.1
Location: 210809..211924 (1116 bp)
Type: Others
Protein ID: WP_239723499.1
Location: 202392..204443 (2052 bp)
Type: Others
Protein ID: WP_276553232.1
Location: 204478..206517 (2040 bp)
Type: Others
Protein ID: WP_061559438.1
Location: 206504..206638 (135 bp)
Type: Others
Protein ID: WP_254902471.1
Location: 206724..207227 (504 bp)
Type: Others
Protein ID: WP_061559439.1
Location: 208211..208561 (351 bp)
Type: Others
Protein ID: WP_061559441.1
Location: 208681..210282 (1602 bp)
Type: Others
Protein ID: WP_061559442.1
Location: 212014..212745 (732 bp)
Type: Others
Protein ID: WP_082811594.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MJO58_RS28780202392..204443-2052WP_276553232.1serine/threonine-protein kinase-
MJO58_RS28400 (MJO58_28225)204478..206517-2040WP_061559438.1serine/threonine-protein kinase-
MJO58_RS28405 (MJO58_28725)206504..206638-135WP_254902471.1hypothetical protein-
MJO58_RS28410 (MJO58_28230)206724..207227-504WP_061559439.1hypothetical protein-
MJO58_RS28415 (MJO58_28235)207364..207630+267WP_061559440.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
MJO58_RS28420 (MJO58_28240)207635..208030+396WP_061560252.1type II toxin-antitoxin system VapC family toxinToxin
MJO58_RS28425 (MJO58_28245)208211..208561-351WP_061559441.1hypothetical protein-
MJO58_RS28430 (MJO58_28250)208681..210282-1602WP_061559442.1DUF5631 domain-containing protein-
MJO58_RS28435 (MJO58_28255)210809..211924+1116WP_239723499.1IS110 family transposase-
MJO58_RS28440 (MJO58_28260)212014..212745-732WP_082811594.1sensor domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..224738224738


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 13974.10 Da        Isoelectric Point: 6.0687

>T236078 WP_061560252.1 NZ_CP092424:207635-208030 [Mycobacterium lentiflavum]
MRIYLDTSALVKLVVVEAESVALQNFLAEQRHDTLFSAALARTELIRAVSPNGPQAIGHARDLLHGLDIITLSRQLLDDA
GTLQPLTLRSLDAIHLVAAQRAGDTLRTVITYDARMVAAAAELGIPTAAPG

Download         Length: 396 bp

>T236078 NZ_LR135281:32363-32620 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9800.95 Da        Isoelectric Point: 4.6652

>AT236078 WP_061559440.1 NZ_CP092424:207364-207630 [Mycobacterium lentiflavum]
MRAIGVRELRQNASKYLEDVAAGESIEITDRGRPVARLVPVTGDPWQDLVNSGEVVLAARPLKADDLEPQSYPHSPTEAL
EQLRHDER

Download         Length: 267 bp

>AT236078 NZ_LR135281:32101-32370 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1X0XNF8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1X0XN39

References