Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 65362..65906 Replicon plasmid unnamed1
Accession NZ_CP092424
Organism Mycobacterium lentiflavum strain ATCC 51985

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MJO58_RS27770 Protein ID WP_084954129.1
Coordinates 65362..65640 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0E4H3K5
Locus tag MJO58_RS27775 Protein ID WP_061559515.1
Coordinates 65637..65906 (-) Length 90 a.a.

Genomic Context

MJO58_RS27755MJO58_RS27765MJO58_RS27780MJO58_RS27795MJO58_RS27750MJO58_RS27760MJO58_RS27770MJO58_RS27775MJO58_RS27785MJO58_RS27790MJO58_RS27800
Location: 61715..62395 (681 bp)
Type: Others
Protein ID: WP_061559513.1
Location: 64987..65148 (162 bp)
Type: Others
Protein ID: WP_239723505.1
Location: 66685..67140 (456 bp)
Type: Others
Protein ID: WP_061559516.1
Location: 68673..68777 (105 bp)
Type: Others
Protein ID: WP_082811763.1
Location: 60678..61187 (510 bp)
Type: Others
Protein ID: Protein_54
Location: 63238..64658 (1421 bp)
Type: Others
Protein ID: Protein_56
Location: 65362..65640 (279 bp)
Type: Toxin
Protein ID: WP_084954129.1
Location: 65637..65906 (270 bp)
Type: Antitoxin
Protein ID: WP_061559515.1
Location: 67232..67801 (570 bp)
Type: Others
Protein ID: WP_061559517.1
Location: 67798..68319 (522 bp)
Type: Others
Protein ID: WP_239723506.1
Location: 68840..69028 (189 bp)
Type: Others
Protein ID: Protein_64
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MJO58_RS27750 (MJO58_27575)60678..61187-510Protein_54sulfite exporter TauE/SafE family protein-
MJO58_RS27755 (MJO58_27580)61715..62395+681WP_061559513.1response regulator transcription factor-
MJO58_RS27760 (MJO58_27585)63238..64658-1421Protein_56IS3 family transposase-
MJO58_RS27765 (MJO58_27590)64987..65148+162WP_239723505.1hypothetical protein-
MJO58_RS27770 (MJO58_27595)65362..65640-279WP_084954129.1type II toxin-antitoxin system RelE/ParE family toxinToxin
MJO58_RS27775 (MJO58_27600)65637..65906-270WP_061559515.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
MJO58_RS27780 (MJO58_27605)66685..67140+456WP_061559516.1hypothetical protein-
MJO58_RS27785 (MJO58_27610)67232..67801-570WP_061559517.1hypothetical protein-
MJO58_RS27790 (MJO58_27615)67798..68319-522WP_239723506.1helix-turn-helix transcriptional regulator-
MJO58_RS27795 (MJO58_27620)68673..68777+105WP_082811763.1DUF1330 domain-containing protein-
MJO58_RS27800 (MJO58_27625)68840..69028-189Protein_64FAD-dependent oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..224738224738
-flankIS/Tn--63238..642601022


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10587.13 Da        Isoelectric Point: 10.5216

>T236077 WP_084954129.1 NZ_CP092424:c65640-65362 [Mycobacterium lentiflavum]
VTENDDAWSVQVSPAAARALERLPHKVAAAIAEFITVALPADPLRMSKPLRFQFEGWRVARRGDYRVTFRILSDDNVLYV
GRIEHRAHVYRR

Download         Length: 279 bp

>T236077 NZ_LR135279:c218535-218263 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9530.58 Da        Isoelectric Point: 4.4262

>AT236077 WP_061559515.1 NZ_CP092424:c65906-65637 [Mycobacterium lentiflavum]
MKQVPLSEAKDKLSALVDEADTTHEIIQITRHGRVAAVIMSADDLDSLNETLHALGTPGLADELAQADADYAAGNTVSGN
DIRRRYGLQ

Download         Length: 270 bp

>AT236077 NZ_LR135279:c218798-218535 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E4H3K5

References