Detailed information of TA system TA236073

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 2380535..2381164
• Replicon: chromosome
• Accession: NZ_CP092419
• Organism: Leptolyngbya boryana IU 594

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MCP04_RS11310
• Protein ID: WP_017286993.1
• Coordinates: 2380535..2380936 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1Z4JFE3
• Locus tag: MCP04_RS11315
• Protein ID: WP_017286994.1
• Coordinates: 2380937..2381164 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MCP04_RS11290 (MCP04_11290)	2376922..2378280	-	1359	WP_017286989.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
MCP04_RS11295 (MCP04_11295)	2378277..2378843	-	567	WP_017286990.1	GNAT family N-acetyltransferase	-
MCP04_RS11300 (MCP04_11300)	2378850..2380268	-	1419	WP_017286991.1	YdiU family protein	-
MCP04_RS11305 (MCP04_11305)	2380293..2380538	-	246	WP_017286992.1	nucleotidyltransferase domain-containing protein	-
MCP04_RS11310 (MCP04_11310)	2380535..2380936	-	402	WP_017286993.1	type II toxin-antitoxin system VapC family toxin	Toxin
MCP04_RS11315 (MCP04_11315)	2380937..2381164	-	228	WP_017286994.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MCP04_RS11320 (MCP04_11320)	2381452..2381763	-	312	WP_144056170.1	hypothetical protein	-
MCP04_RS11325 (MCP04_11325)	2382216..2382593	-	378	WP_017286997.1	nuclear transport factor 2 family protein	-
MCP04_RS11330 (MCP04_11330)	2382919..2383227	-	309	WP_017286998.1	hypothetical protein	-
MCP04_RS11335 (MCP04_11335)	2383330..2383590	-	261	WP_017286999.1	hypothetical protein	-
MCP04_RS11340 (MCP04_11340)	2383690..2384535	-	846	WP_017287000.1	trypsin-like peptidase domain-containing protein	-
MCP04_RS11345 (MCP04_11345)	2384738..2385970	-	1233	WP_017287001.1	Zn-dependent hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14816.21 Da
• Isoelectric Point: 5.8399

>T236073 WP_017286993.1 NZ_CP092419:c2380936-2380535 [Leptolyngbya boryana IU 594]
MQYLLDTNICIYLIKQRPPKVLERFSNLALSDIGISSITVAELEYGVCKSQQREKNRNALMQFLIPLEIVAFDQAAATLY
GAIRSDLESRGLVIGAMDMLIAAHALSLSVTLVSNNVREFSRIANLSLQNWAE

Nucleotide

• Length: 402 bp

>T236073 NZ_LR135259:c134383-134111 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8511.74 Da
• Isoelectric Point: 4.5007

>AT236073 WP_017286994.1 NZ_CP092419:c2381164-2380937 [Leptolyngbya boryana IU 594]
MNIAKLSTDGTHQIVILPEDCKMTGTEVYIKKVGSAIVLIAKDHPWQSLFDSLEQFSEDFMTTREQPPLDVREAF

Nucleotide

• Length: 228 bp

>AT236073 NZ_LR135259:c134646-134383 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1Z4JFE3