Detailed information of TA system TA236065

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 3640521..3641116
• Replicon: chromosome
• Accession: NZ_CP092417
• Organism: Endozoicomonas sp. SCSIO W0465

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: MJO57_RS16395
• Protein ID: WP_252017328.1
• Coordinates: 3640775..3641116 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: -
• Locus tag: MJO57_RS16390
• Protein ID: WP_252017327.1
• Coordinates: 3640521..3640778 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJO57_RS16340 (MJO57_16265)	3636421..3636831	-	411	WP_252017320.1	transposase DNA-binding-containing protein	-
MJO57_RS16345 (MJO57_16270)	3636880..3637194	-	315	WP_252017321.1	transposase DNA-binding-containing protein	-
MJO57_RS16350 (MJO57_16275)	3637315..3637809	+	495	WP_252017322.1	hypothetical protein	-
MJO57_RS16355 (MJO57_16280)	3637810..3638373	-	564	WP_252017323.1	IS3 family transposase	-
MJO57_RS16360 (MJO57_16285)	3638394..3638618	-	225	WP_252017324.1	IS3 family transposase	-
MJO57_RS16365 (MJO57_16290)	3638678..3638980	-	303	WP_252017325.1	transposase	-
MJO57_RS16370 (MJO57_16295)	3639047..3639160	+	114	Protein_3245	recombinase family protein	-
MJO57_RS16375 (MJO57_16300)	3639143..3639307	+	165	WP_256493350.1	helix-turn-helix domain-containing protein	-
MJO57_RS16380 (MJO57_16305)	3639300..3639782	-	483	WP_252026893.1	IS1595 family transposase	-
MJO57_RS16385 (MJO57_16310)	3639968..3640237	-	270	WP_252017326.1	transposase	-
MJO57_RS16390 (MJO57_16315)	3640521..3640778	+	258	WP_252017327.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
MJO57_RS16395 (MJO57_16320)	3640775..3641116	+	342	WP_252017328.1	type II toxin-antitoxin system ChpB family toxin	Toxin
MJO57_RS16400 (MJO57_16325)	3641407..3642524	+	1118	WP_252027047.1	IS3 family transposase	-
MJO57_RS16405 (MJO57_16330)	3642568..3644754	+	2187	WP_256493351.1	host specificity factor TipJ family phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3611817..3644754	32937

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-112)

Antitoxin

• SpoVT-AbrB domain (6-47)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12083.98 Da
• Isoelectric Point: 7.7915

>T236065 WP_252017328.1 NZ_CP092417:3640775-3641116 [Endozoicomonas sp. SCSIO W0465]
MSVYERGDIVRVNLNPVSGSEVQGESRPCLVLSVKAFNCLGSTLVAPITQGGNYARVQGFTVPLMGTGTETQGVVLINGV
RMIDLRARQSRKVESAPEALVNEVLAKLQAIIE

Nucleotide

• Length: 342 bp

>T236065 NZ_LR135254:183540-183806 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9336.67 Da
• Isoelectric Point: 4.3855

>AT236065 WP_252017327.1 NZ_CP092417:3640521-3640778 [Endozoicomonas sp. SCSIO W0465]
MNTVIRRIGNSSGAIIPSELLRRLNLKDGDSVVIAEVKNSLVITKATNRPHYSIDELLAQCDLSASMPEELTEWDSILPA
GDEML

Nucleotide

• Length: 258 bp

>AT236065 NZ_LR135254:183277-183540 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA