Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3264843..3265426 Replicon chromosome
Accession NZ_CP092417
Organism Endozoicomonas sp. SCSIO W0465

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MJO57_RS14500 Protein ID WP_252026328.1
Coordinates 3265172..3265426 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MJO57_RS14495 Protein ID WP_252026326.1
Coordinates 3264843..3265175 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJO57_RS14455 (MJO57_14385) 3260039..3260245 - 207 WP_252026314.1 hypothetical protein -
MJO57_RS14460 (MJO57_14390) 3260309..3260827 + 519 WP_252026316.1 hypothetical protein -
MJO57_RS14465 (MJO57_14395) 3260817..3261194 + 378 WP_252026317.1 hypothetical protein -
MJO57_RS14470 (MJO57_14400) 3261191..3261400 + 210 WP_252026319.1 hypothetical protein -
MJO57_RS14475 (MJO57_14405) 3261403..3261831 + 429 WP_252026321.1 hypothetical protein -
MJO57_RS14480 (MJO57_14410) 3261863..3262321 + 459 WP_252026323.1 phage tail tube protein -
MJO57_RS14485 (MJO57_14415) 3262318..3262650 + 333 WP_252026324.1 hypothetical protein -
MJO57_RS32780 3262707..3262835 + 129 WP_256493297.1 hypothetical protein -
MJO57_RS14490 (MJO57_14420) 3262835..3264766 + 1932 WP_252026325.1 phage tail tape measure C-terminal domain-containing protein -
MJO57_RS14495 (MJO57_14425) 3264843..3265175 - 333 WP_252026326.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MJO57_RS14500 (MJO57_14430) 3265172..3265426 - 255 WP_252026328.1 type II toxin-antitoxin system HicA family toxin Toxin
MJO57_RS14505 (MJO57_14435) 3265497..3265847 + 351 WP_252026330.1 hypothetical protein -
MJO57_RS14510 (MJO57_14440) 3265819..3266289 + 471 WP_252026332.1 hypothetical protein -
MJO57_RS14515 (MJO57_14445) 3266259..3267563 + 1305 WP_252026334.1 hypothetical protein -
MJO57_RS14520 (MJO57_14450) 3267676..3269013 - 1338 WP_252017304.1 transposase -
MJO57_RS14525 (MJO57_14455) 3269039..3269791 + 753 WP_252026336.1 hypothetical protein -
MJO57_RS14530 (MJO57_14460) 3269792..3270082 + 291 WP_252026337.1 hypothetical protein -
MJO57_RS14535 (MJO57_14465) 3270085..3270342 + 258 WP_252026339.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3234864..3280362 45498


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-74)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9500.01 Da        Isoelectric Point: 11.2749

>T236063 WP_252026328.1 NZ_CP092417:c3265426-3265172 [Endozoicomonas sp. SCSIO W0465]
MKKKHATTLRKLFARPISGSIHWADIESLFIALGARIEEREGSRVKVVLFGEVRIFHRPHPSPDTDKGAVASIRRWLENN
GVTP

Download         Length: 255 bp

>T236063 NZ_LR135246:c20890-20705 [Enterococcus faecium]
ATGCCACTTACGGGAAAAGAAATGCTTAAGTTATTGAAAAAAAATGGCTGGGTTGAGCGAAGGCAAGAGGGATCTCATCA
TCATCTTTATAAGGATGGTGTTAGAATCACTGTTCCTGTTCATGCCAATCAAGATCTTGGCCGAGGACTTGAGCGAAAAA
TTTTGAAGGATGCGGGATTGAAATAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12040.62 Da        Isoelectric Point: 4.8181

>AT236063 WP_252026326.1 NZ_CP092417:c3265175-3264843 [Endozoicomonas sp. SCSIO W0465]
MINQMTINGYIAVITYDPEIDLFRGEFVGLNGGADFYAADVKSLHQEGKVSLKVFLDACKEEGIEPRKAFSGKLNLRIDP
DLHESASVAAAASNRSLNQLINDALRQSLN

Download         Length: 333 bp

>AT236063 NZ_LR135246:c20671-20240 [Enterococcus faecium]
ATGTTAAGTGAGCCTTTAGCAAAAACCTATCCTGCTATTTTTAGCCCAGAAGAAGGTGGTGGGTACTTTATTGAATTTCC
TGATGTTCAAGGTGCTTACACAGGAATTAACGAAGACGATATATCTTATGGGATTGCTATGGCACAAGAGGTGTTAGGTA
TGGTTTTAGCAGATTATATTGAGCATGAAGATCTACTTCCAGAACCAACACCAATCAATAAGATTTCTGTTGAAGATGAT
TCTTTTACTACTTTAATTCGTGTAGATGTTGCCAAATATTTGAAAGACACAGAACTTGTCAAAAAAACCTTAACAATTCC
TCAATGGGCGGATAAGTTAGGCAAAAGGGCTGGCATAAATTTTTCAGTCCTTCTAACAGAATCAATTGCAGATAAAGCAG
ATAACATTCTTCGTTCTGGAAGAAATAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References