Detailed information of TA system TA236062

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3244537..3245135
• Replicon: chromosome
• Accession: NZ_CP092417
• Organism: Endozoicomonas sp. SCSIO W0465

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MJO57_RS14345
• Protein ID: WP_252026272.1
• Coordinates: 3244905..3245135 (-)
• Length: 77 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MJO57_RS14340
• Protein ID: WP_252026270.1
• Coordinates: 3244537..3244908 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJO57_RS14315 (MJO57_14245)	3239796..3241310	-	1515	WP_252017330.1	IS66 family transposase	-
MJO57_RS14320 (MJO57_14250)	3241482..3242759	+	1278	WP_256491761.1	IS4 family transposase	-
MJO57_RS14325 (MJO57_14255)	3242827..3243363	+	537	WP_252026264.1	hypothetical protein	-
MJO57_RS14330 (MJO57_14260)	3243350..3243535	+	186	WP_252026266.1	hypothetical protein	-
MJO57_RS14335 (MJO57_14265)	3243678..3244535	+	858	WP_252026268.1	hypothetical protein	-
MJO57_RS14340 (MJO57_14270)	3244537..3244908	-	372	WP_252026270.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MJO57_RS14345 (MJO57_14275)	3244905..3245135	-	231	WP_252026272.1	type II toxin-antitoxin system HicA family toxin	Toxin
MJO57_RS14350 (MJO57_14280)	3245413..3245706	+	294	WP_252026274.1	hypothetical protein	-
MJO57_RS14355 (MJO57_14285)	3245712..3245915	+	204	WP_252026276.1	hypothetical protein	-
MJO57_RS14360 (MJO57_14290)	3245919..3246173	+	255	WP_252026278.1	hypothetical protein	-
MJO57_RS14365 (MJO57_14295)	3246656..3247819	+	1164	WP_252026280.1	MT-A70 family methyltransferase	-
MJO57_RS14370 (MJO57_14300)	3247899..3248147	-	249	WP_252026282.1	hypothetical protein	-
MJO57_RS14375 (MJO57_14305)	3248146..3249660	+	1515	WP_252017330.1	IS66 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3234864..3280362	45498

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (13-68)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 77 a.a.
• Molecular weight: 9052.42 Da
• Isoelectric Point: 10.2944

>T236062 WP_252026272.1 NZ_CP092417:c3245135-3244905 [Endozoicomonas sp. SCSIO W0465]
MEKLKDNPKTFPWKDVVRLLTALGYQKEEMSGSRVRFYHKSNKHMLRFHRPHPENHLKGGALKDLIEALNQQDYFS

Nucleotide

• Length: 231 bp

>T236062 NZ_LR135244:c203123-202851 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 14020.89 Da
• Isoelectric Point: 6.4811

>AT236062 WP_252026270.1 NZ_CP092417:c3244908-3244537 [Endozoicomonas sp. SCSIO W0465]
MTQYFNYKGYQGTVEPQIEDGTLYGKLAFIGDLVTYEADTMITLEQEFRRSVDDYLADCAALGKEPDKPFKGVLNVRLGA
ELHRKIGLLVNNRRGKSVNAFICDAVREKLSRIDTEDTLHHHR

Nucleotide

• Length: 372 bp

>AT236062 NZ_LR135244:c203386-203123 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA