Detailed information of TA system TA236061

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1574347..1574915
• Replicon: chromosome
• Accession: NZ_CP092417
• Organism: Endozoicomonas sp. SCSIO W0465

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MJO57_RS06645
• Protein ID: WP_252023914.1
• Coordinates: 1574631..1574915 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MJO57_RS06640
• Protein ID: WP_252026968.1
• Coordinates: 1574347..1574631 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJO57_RS06625 (MJO57_06595)	1569934..1570497	+	564	WP_252023907.1	DNA-3-methyladenine glycosylase I	-
MJO57_RS06630 (MJO57_06600)	1571792..1572481	+	690	WP_252023909.1	reverse transcriptase domain-containing protein	-
MJO57_RS06635 (MJO57_06605)	1573177..1573974	+	798	WP_252023912.1	hypothetical protein	-
MJO57_RS06640 (MJO57_06610)	1574347..1574631	+	285	WP_252026968.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MJO57_RS06645 (MJO57_06615)	1574631..1574915	+	285	WP_252023914.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MJO57_RS06650 (MJO57_06620)	1574999..1575181	-	183	WP_252023916.1	hypothetical protein	-
MJO57_RS06655 (MJO57_06625)	1575240..1575578	-	339	WP_252023917.1	hypothetical protein	-
MJO57_RS06660 (MJO57_06630)	1575571..1575810	-	240	WP_252023919.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MJO57_RS06665 (MJO57_06635)	1576246..1577235	-	990	WP_252023921.1	IS1380 family transposase	-
MJO57_RS06670 (MJO57_06640)	1577237..1577626	-	390	WP_256493240.1	tape measure protein	-
MJO57_RS06675 (MJO57_06645)	1577633..1577959	-	327	WP_252023925.1	hypothetical protein	-
MJO57_RS06680 (MJO57_06650)	1578104..1579618	+	1515	WP_252017330.1	IS66 family transposase	-
MJO57_RS32660	1579605..1579730	-	126	WP_256493241.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-73)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11004.69 Da
• Isoelectric Point: 4.3904

>T236061 WP_252023914.1 NZ_CP092417:1574631-1574915 [Endozoicomonas sp. SCSIO W0465]
MILWEEESLNDREKIFEFLYDFNPEAAEKTDLIIEAKVENLLEQPLMGGEREGIRGRLLIIPEVSMIVSYWVDGKDIRVM
RVLHQKQKFPSDPG

Nucleotide

• Length: 285 bp

>T236061 NZ_LR135244:167503-167844 [Enterococcus faecium]
ATGACTGAAGAAAAAAATTACATTCCTAAAAAGGGAGATATTGTTTGGATTGATTTTGATCCTTCTGCAGGAAAAGAGAT
TCAAAAGCGGCGTCCTGGATTAGTTGTTTCTAGATACGAGTTTAATCGCAAAACAATGTTTGCAGTTATTTGTCCGATTA
CCTCTACTATAAGAAATTTTCCGACACGCTATTCATTACCTACCGAATTAGACACTACTGGACAAATACTTATTTCTCAA
TTGAAGTCGCTCGATTTCAATGAGAGAAAACTTAAAAAAATTGAATCCTTACCTTTACAAGATATGGCGAAAATCGATCA
AATGATTGAATATATATTTTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11009.26 Da
• Isoelectric Point: 8.0741

>AT236061 WP_252026968.1 NZ_CP092417:1574347-1574631 [Endozoicomonas sp. SCSIO W0465]
METRIQFRVDEETKRLAQKMAESQGRTISDACREFTEQLAEQQRKLSSHDQWLTQQVNQAFEKLDSGAADFVEHDKTKDE
MAKRKAKIRNRGSH

Nucleotide

• Length: 285 bp

>AT236061 NZ_LR135244:167273-167503 [Enterococcus faecium]
ATGCTTATTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGATTACTTTGCCTTCTGATAACGGAAAGAAGCCTTCGGA
AAATAAAGAATATATAGTTATCTATTCTGATGATGGAACAATTACTTTGGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GAGAAGAAGCGGAGTATTACGAAAAAGATGAATGGGAAGATTTGTCTCCTGAAGGAAGAGAGATTTTATAA