Detailed information of TA system TA236059

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1051198..1051714
• Replicon: chromosome
• Accession: NZ_CP092417
• Organism: Endozoicomonas sp. SCSIO W0465

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MJO57_RS04485
• Protein ID: WP_252023296.1
• Coordinates: 1051445..1051714 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MJO57_RS04480
• Protein ID: WP_252023294.1
• Coordinates: 1051198..1051455 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJO57_RS04445 (MJO57_04425)	1046723..1048117	+	1395	WP_252023284.1	group II intron reverse transcriptase/maturase	-
MJO57_RS04450 (MJO57_04430)	1048422..1048661	+	240	WP_252023285.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
MJO57_RS04455 (MJO57_04435)	1048658..1049098	+	441	WP_252023286.1	type II toxin-antitoxin system VapC family toxin	-
MJO57_RS04460 (MJO57_04440)	1049117..1049947	+	831	WP_252023287.1	DUF1338 domain-containing protein	-
MJO57_RS04465 (MJO57_04445)	1049957..1050193	+	237	WP_252023288.1	DUF29 family protein	-
MJO57_RS04470 (MJO57_04450)	1050248..1050610	+	363	WP_252023289.1	hypothetical protein	-
MJO57_RS04475 (MJO57_04455)	1050676..1050876	-	201	WP_252023291.1	cadherin-like domain-containing protein	-
MJO57_RS04480 (MJO57_04460)	1051198..1051455	+	258	WP_252023294.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MJO57_RS04485 (MJO57_04465)	1051445..1051714	+	270	WP_252023296.1	Txe/YoeB family addiction module toxin	Toxin
MJO57_RS04490 (MJO57_04470)	1051628..1052458	-	831	WP_252023298.1	Uma2 family endonuclease	-
MJO57_RS04495 (MJO57_04475)	1052488..1052856	+	369	WP_252023300.1	hypothetical protein	-
MJO57_RS04500 (MJO57_04480)	1052870..1053022	+	153	WP_252023302.1	hypothetical protein	-
MJO57_RS04505 (MJO57_04485)	1053138..1053377	+	240	WP_252023304.1	hypothetical protein	-
MJO57_RS04510 (MJO57_04490)	1053358..1054785	+	1428	WP_252017676.1	IS4 family transposase	-
MJO57_RS04515 (MJO57_04495)	1054795..1055355	+	561	Protein_891	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (10-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10819.28 Da
• Isoelectric Point: 9.5677

>T236059 WP_252023296.1 NZ_CP092417:1051445-1051714 [Endozoicomonas sp. SCSIO W0465]
MTSKQRHLCWSHNAWNDYLYWQEQDRKTLKRINKLITECLRDPFSGLGKPEPLKGNWQGFWSRRISDEHRLIYQPSDTHL
TIAACRFHY

Nucleotide

• Length: 270 bp

>T236059 NZ_LR135243:515367-515708 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9397.55 Da
• Isoelectric Point: 4.7293

>AT236059 WP_252023294.1 NZ_CP092417:1051198-1051455 [Endozoicomonas sp. SCSIO W0465]
MKVVSYSEARNNLKSLLDQVAEDASETIIHRRDGQDAVLMSLASYNSLMETLHLMSSPANAKHLNDSIEQIRGGQIVDKG
LLDDQ

Nucleotide

• Length: 258 bp

>AT236059 NZ_LR135243:515137-515367 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG