Detailed information of TA system TA236054

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 5100651..5101167
• Replicon: chromosome
• Accession: NZ_CP092411
• Organism: Pseudomonas palleroniana strain Q1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MJP36_RS22850
• Protein ID: WP_244384055.1
• Coordinates: 5100880..5101167 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0X7K790
• Locus tag: MJP36_RS22845
• Protein ID: WP_060753830.1
• Coordinates: 5100651..5100890 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJP36_RS22820 (MJP36_22820)	5096169..5097071	-	903	WP_060753829.1	LysR family transcriptional regulator	-
MJP36_RS22825 (MJP36_22825)	5097268..5098146	+	879	WP_244384051.1	hypothetical protein	-
MJP36_RS22830 (MJP36_22830)	5098215..5098754	-	540	WP_244384052.1	hypothetical protein	-
MJP36_RS22835 (MJP36_22835)	5098753..5099043	+	291	WP_244384053.1	hypothetical protein	-
MJP36_RS22840 (MJP36_22840)	5099000..5100226	+	1227	WP_244384054.1	MFS transporter	-
MJP36_RS22845 (MJP36_22845)	5100651..5100890	+	240	WP_060753830.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MJP36_RS22850 (MJP36_22850)	5100880..5101167	+	288	WP_244384055.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MJP36_RS22860 (MJP36_22860)	5101428..5102141	-	714	WP_010212191.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
MJP36_RS22865 (MJP36_22865)	5102169..5102927	-	759	WP_104995791.1	MBL fold metallo-hydrolase	-
MJP36_RS22870 (MJP36_22870)	5102932..5104047	-	1116	WP_161549701.1	outer membrane protein assembly factor BamC	-
MJP36_RS22875 (MJP36_22875)	5104065..5104943	-	879	WP_090366213.1	4-hydroxy-tetrahydrodipicolinate synthase	-
MJP36_RS22880 (MJP36_22880)	5105217..5105777	+	561	WP_003172487.1	glycine cleavage system protein R	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11334.18 Da
• Isoelectric Point: 10.1270

>T236054 WP_244384055.1 NZ_CP092411:5100880-5101167 [Pseudomonas palleroniana]
MIYSLDFDARALKEWQKLGNTIRQQLKKKLMEILNDPRIEANRLHGLPDCYKIKLRSSGYRLVYQVIDHEITVFVVAVDK
RERDRVYQRAAERLS

Nucleotide

• Length: 288 bp

>T236054 NZ_LR135236:c154830-154558 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9096.54 Da
• Isoelectric Point: 4.8011

>AT236054 WP_060753830.1 NZ_CP092411:5100651-5100890 [Pseudomonas palleroniana]
MASINIRIDDDLKARAYLELERLGVTPSELMRQTLQYVVERGQLPFKPVLMTEDDEALLAKVRERLASPQRVRVSIDDL

Nucleotide

• Length: 240 bp

>AT236054 NZ_LR135236:c155093-154830 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0X7K790