Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 130421..131157 Replicon plasmid Kp27-unnamed1
Accession NZ_CP092401
Organism Klebsiella pneumoniae strain NC-01

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag KZ666_RS28085 Protein ID WP_261949597.1
Coordinates 130675..131157 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag KZ666_RS28080 Protein ID WP_261949596.1
Coordinates 130421..130687 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ666_RS28070 (KZ666_28250) 127247..128641 + 1395 WP_261949594.1 6-phospho-beta-glucosidase -
KZ666_RS28075 (KZ666_28255) 128717..130264 + 1548 WP_261949595.1 sulfatase-like hydrolase/transferase -
KZ666_RS28080 (KZ666_28260) 130421..130687 + 267 WP_261949596.1 DUF1778 domain-containing protein Antitoxin
KZ666_RS28085 (KZ666_28265) 130675..131157 + 483 WP_261949597.1 GNAT family N-acetyltransferase Toxin
KZ666_RS28090 (KZ666_28270) 131360..132763 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
KZ666_RS28095 (KZ666_28275) 132792..133424 - 633 WP_001567369.1 hypothetical protein -
KZ666_RS28100 (KZ666_28280) 134010..134408 - 399 WP_004026629.1 H-NS family nucleoid-associated regulatory protein -
KZ666_RS28105 (KZ666_28285) 134812..135630 - 819 WP_032437803.1 phospholipase D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..299847 299847
- flank IS/Tn - - 131360..132763 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17516.19 Da        Isoelectric Point: 9.5608

>T236043 WP_261949597.1 NZ_CP092401:130675-131157 [Klebsiella pneumoniae]
VGRVTAPEPLTSVHQLAEFVSGETVLDDWLKQRGLKNQALGAARTFVVCKKNTKQVVGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSFHGKGLGADLLHDAVLRCYRVSENIGVRAIVVHALTEESKGFYIHHGFKASQTEERTLFLKIP

Download         Length: 483 bp

>T236043 NZ_LR135220:c152398-152126 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.51 Da        Isoelectric Point: 4.6027

>AT236043 WP_261949596.1 NZ_CP092401:130421-130687 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDTAAEILHKSRTDFILEMACQAAENVILDRCVFNFNDKQYAEFIDILDAPVAEDPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT236043 NZ_LR135220:c152661-152398 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References