Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 166083..166828 | Replicon | plasmid Kp27-unnamed2 |
| Accession | NZ_CP092400 | ||
| Organism | Klebsiella pneumoniae strain NC-01 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A331KSM6 |
| Locus tag | KZ666_RS27235 | Protein ID | WP_032408901.1 |
| Coordinates | 166337..166828 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | - |
| Locus tag | KZ666_RS27230 | Protein ID | WP_014386183.1 |
| Coordinates | 166083..166349 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZ666_RS27180 (KZ666_27360) | 161635..162048 | - | 414 | WP_046623943.1 | helix-turn-helix domain-containing protein | - |
| KZ666_RS27185 (KZ666_27365) | 162049..162327 | - | 279 | WP_004152721.1 | helix-turn-helix transcriptional regulator | - |
| KZ666_RS27190 (KZ666_27370) | 162317..162637 | - | 321 | WP_014386190.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KZ666_RS27195 (KZ666_27375) | 162718..162942 | - | 225 | WP_014386189.1 | hypothetical protein | - |
| KZ666_RS27200 (KZ666_27380) | 162953..163165 | - | 213 | WP_014386188.1 | hypothetical protein | - |
| KZ666_RS27205 (KZ666_27385) | 163227..163553 | - | 327 | WP_014386187.1 | hypothetical protein | - |
| KZ666_RS27210 (KZ666_27390) | 164190..164540 | - | 351 | WP_014386186.1 | hypothetical protein | - |
| KZ666_RS27215 (KZ666_27395) | 164537..164809 | - | 273 | WP_032408902.1 | hypothetical protein | - |
| KZ666_RS27220 (KZ666_27400) | 164999..165484 | + | 486 | WP_014386185.1 | hypothetical protein | - |
| KZ666_RS27225 (KZ666_27405) | 165728..165886 | - | 159 | WP_014386184.1 | type I toxin-antitoxin system Hok family toxin | - |
| KZ666_RS27230 (KZ666_27410) | 166083..166349 | + | 267 | WP_014386183.1 | DUF1778 domain-containing protein | Antitoxin |
| KZ666_RS27235 (KZ666_27415) | 166337..166828 | + | 492 | WP_032408901.1 | GNAT family N-acetyltransferase | Toxin |
| KZ666_RS27240 (KZ666_27420) | 167269..167520 | - | 252 | WP_032408900.1 | aldo/keto reductase | - |
| KZ666_RS27245 (KZ666_27425) | 167717..169309 | - | 1593 | Protein_183 | IS66 family transposase | - |
| KZ666_RS27250 (KZ666_27430) | 169340..169690 | - | 351 | WP_014386180.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| KZ666_RS27255 (KZ666_27435) | 169687..170127 | - | 441 | WP_014386179.1 | transposase | - |
| KZ666_RS27260 (KZ666_27440) | 170389..171144 | - | 756 | WP_032408898.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..210837 | 210837 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17667.46 Da Isoelectric Point: 8.8757
>T236040 WP_032408901.1 NZ_CP092400:166337-166828 [Klebsiella pneumoniae]
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT
Download Length: 492 bp
>T236040 NZ_LR135219:183354-183620 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10090.66 Da Isoelectric Point: 5.1169
>AT236040 WP_014386183.1 NZ_CP092400:166083-166349 [Klebsiella pneumoniae]
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK
Download Length: 267 bp
>AT236040 NZ_LR135219:183091-183354 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|