Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/GNAT-DUF1778
Location 187795..188546 Replicon plasmid Kp23-unnamed1
Accession NZ_CP092398
Organism Klebsiella pneumoniae strain PA-01

Toxin (Protein)


Gene name ataT Uniprot ID A0A8T3UHS1
Locus tag KZ665_RS26650 Protein ID WP_004883482.1
Coordinates 188064..188546 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A8T3UKU4
Locus tag KZ665_RS26645 Protein ID WP_004883484.1
Coordinates 187795..188073 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ665_RS26625 182951..184912 + 1962 WP_112029085.1 sigma 54-interacting transcriptional regulator -
KZ665_RS26630 185088..185492 + 405 WP_086528925.1 DUF2251 domain-containing protein -
KZ665_RS26635 185827..186660 + 834 WP_004883492.1 GIY-YIG nuclease family protein -
KZ665_RS26640 186765..186989 + 225 WP_226879455.1 bacteriocin immunity protein -
KZ665_RS26645 187795..188073 + 279 WP_004883484.1 DUF1778 domain-containing protein Antitoxin
KZ665_RS26650 188064..188546 + 483 WP_004883482.1 GNAT family N-acetyltransferase Toxin
KZ665_RS26655 188599..189081 - 483 WP_004196929.1 hypothetical protein -
KZ665_RS26660 189460..190959 - 1500 WP_086528915.1 lipopolysaccharide kinase InaA family protein -
KZ665_RS26665 190987..192720 - 1734 WP_032412835.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..307227 307227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(69-145)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17491.36 Da        Isoelectric Point: 9.4950

>T236035 WP_004883482.1 NZ_CP092398:188064-188546 [Klebsiella pneumoniae]
MGMRPPEPLTPEHNIAEFCCQDQVINEWLKKKALRNHGTGISRVFVVCSENSKRVIAYYCLSSGSVHRNTVTGTYRRNAP
AAIPVIVLGRLAVDAAWAGKGIGAALLKDAIYRTEHIAVQVGVRALLVHALNDEVVAFYTKFGFETSAVNALTLLFPVKV

Download         Length: 483 bp

>T236035 NZ_LR135204:44675-44860 [Enterococcus faecium]
ATGCCACTTACGGGAAAAGAAATGCTTAAGTTATTGAAAAAAAATGGCTGGGTTGAGCGAAGGCAAGAGGGATCTCATCA
TCATCTTTATAAGGATGGTGTTAGAATCACTGTTCCTGTTCATGCCAATCAAGATCTTGGCCGAGGACTTGAGCAAAAAA
TTTTAAAGGATGCGGGATTGAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10720.23 Da        Isoelectric Point: 4.5423

>AT236035 WP_004883484.1 NZ_CP092398:187795-188073 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEAACREAQDILLDQRLFLLDDKQFDTFIEELDAPVTPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT236035 NZ_LR135204:44894-45325 [Enterococcus faecium]
ATGTTAAGTGAGCCTTTAGCAAAAACCTATCCTGCTATTTTTAGCCCAGAAGAAGGTGGTGGGTACTTTATTGAATTTCC
TGATGTTCAAGGTGCTTACACAGGAATTAACGAAGACGATATATCTTATGGAATTGCTATGGCACAAGAGGTGTTAGGTA
TGGTTTTAGCAGATTATATTGAGCATGAAGATCTACTTCCAGAACCAACACCAATCAATAAGATTTCTGTTGAAGATGAT
TCTTTTACTACTTTAATTCGTGTAGATGTTGCCAAATATTTGAAAGACACAGAACTTGTCAAAAAAACCTTAACAATTCC
TCAATGGGCGGATAAGCTAGGCAAAAGGGCTGGCATAAATTTTTCAGTCCTTCTAACAGAATCAATTGCAGATAAAGCAG
ATAACATTCTTCGTTCTGGAAGAAATAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References