236034

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 148963..149485 Replicon plasmid Kp23-unnamed1
Accession NZ_CP092398
Organism Klebsiella pneumoniae strain PA-01

Toxin (Protein)


Gene name stbE Uniprot ID A0A0C7KG00
Locus tag KZ665_RS26440 Protein ID WP_038991638.1
Coordinates 148963..149247 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag KZ665_RS26445 Protein ID WP_004181777.1
Coordinates 149237..149485 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ665_RS26410 144941..145312 + 372 WP_038990214.1 hypothetical protein -
KZ665_RS26415 145357..146544 - 1188 WP_112029081.1 RNA-guided endonuclease TnpB family protein -
KZ665_RS26420 146580..147008 + 429 WP_077255446.1 IS200/IS605 family transposase -
KZ665_RS26425 147087..147311 + 225 Protein_140 transposase -
KZ665_RS26430 147583..148809 - 1227 WP_232580119.1 transposase -
KZ665_RS26435 148845..148946 + 102 Protein_142 IS200/IS605 family transposase -
KZ665_RS26440 148963..149247 - 285 WP_038991638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZ665_RS26445 149237..149485 - 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KZ665_RS26450 149776..151575 + 1800 WP_038991636.1 ATP-dependent helicase -
KZ665_RS26455 151909..152895 + 987 WP_025368599.1 hypothetical protein -
KZ665_RS26460 153040..153393 + 354 WP_004181774.1 hypothetical protein -
KZ665_RS26465 153440..154276 + 837 WP_223686625.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..307227 307227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10993.73 Da        Isoelectric Point: 10.6516

>T236034 WP_038991638.1 NZ_CP092398:c149247-148963 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN

Download         Length: 285 bp

>T236034 NZ_LR135203:541057-541398 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCAGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT236034 WP_004181777.1 NZ_CP092398:c149485-149237 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT236034 NZ_LR135203:540827-541057 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7KG00

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References