Detailed information of TA system TA236026

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 3134956..3135512
• Replicon: chromosome
• Accession: NZ_CP092382
• Organism: Xanthomonas oryzae strain PXO339

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MJJ08_RS14930
• Protein ID: WP_229001948.1
• Coordinates: 3134956..3135207 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: MJJ08_RS14935
• Protein ID: WP_011408759.1
• Coordinates: 3135234..3135512 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJJ08_RS14885 (MJJ08_14865)	3130726..3131817	+	1092	WP_041182166.1	ribonuclease D	-
MJJ08_RS14890 (MJJ08_14870)	3131893..3132230	-	338	Protein_2847	ATP-dependent DNA ligase	-
MJJ08_RS14895 (MJJ08_14875)	3132512..3132688	-	177	Protein_2848	DUF3606 domain-containing protein	-
MJJ08_RS14900 (MJJ08_14880)	3132910..3133311	+	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
MJJ08_RS14910	3133742..3133870	-	129	WP_012444694.1	hypothetical protein	-
MJJ08_RS14915 (MJJ08_14890)	3133839..3133958	-	120	Protein_2851	IS3 family transposase	-
MJJ08_RS14920 (MJJ08_14895)	3134175..3134429	-	255	WP_223293127.1	hypothetical protein	-
MJJ08_RS14925 (MJJ08_14900)	3134498..3134695	-	198	WP_004541336.1	hypothetical protein	-
MJJ08_RS14930 (MJJ08_14905)	3134956..3135207	-	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MJJ08_RS14935 (MJJ08_14910)	3135234..3135512	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
MJJ08_RS14940 (MJJ08_14915)	3135708..3136052	-	345	WP_199285675.1	hypothetical protein	-
MJJ08_RS14945 (MJJ08_14920)	3136958..3138142	-	1185	WP_011408397.1	IS256-like element IS1113 family transposase	-
MJJ08_RS14950 (MJJ08_14925)	3138723..3139688	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
MJJ08_RS14955 (MJJ08_14930)	3139838..3140395	+	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T236026 WP_229001948.1 NZ_CP092382:c3135207-3134956 [Xanthomonas oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T236026 NZ_LR135191:516911-517252 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT236026 WP_011408759.1 NZ_CP092382:c3135512-3135234 [Xanthomonas oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT236026 NZ_LR135191:516681-516911 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2