Detailed information of TA system TA236015

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2644823..2645379
• Replicon: chromosome
• Accession: NZ_CP092380
• Organism: Xanthomonas oryzae strain GD1358

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MJJ09_RS12470
• Protein ID: WP_229001948.1
• Coordinates: 2644823..2645074 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: MJJ09_RS12475
• Protein ID: WP_011408759.1
• Coordinates: 2645101..2645379 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJJ09_RS12420 (MJJ09_12395)	2640593..2641684	+	1092	WP_041182166.1	ribonuclease D	-
MJJ09_RS12425 (MJJ09_12400)	2641760..2642097	-	338	Protein_2364	ATP-dependent DNA ligase	-
MJJ09_RS12430 (MJJ09_12405)	2642379..2642555	-	177	Protein_2365	DUF3606 domain-containing protein	-
MJJ09_RS12435 (MJJ09_12410)	2642777..2643178	+	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
MJJ09_RS12445	2643609..2643737	-	129	WP_012444694.1	hypothetical protein	-
MJJ09_RS12450 (MJJ09_12420)	2643706..2643825	-	120	Protein_2368	IS3 family transposase	-
MJJ09_RS12455 (MJJ09_12425)	2644042..2644296	-	255	WP_223293127.1	hypothetical protein	-
MJJ09_RS12460	2644365..2644499	-	135	WP_011051575.1	hypothetical protein	-
MJJ09_RS12465 (MJJ09_12430)	2644492..2644746	-	255	WP_198912806.1	hypothetical protein	-
MJJ09_RS12470 (MJJ09_12435)	2644823..2645074	-	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MJJ09_RS12475 (MJJ09_12440)	2645101..2645379	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
MJJ09_RS12480 (MJJ09_12445)	2645575..2645919	-	345	WP_199285675.1	hypothetical protein	-
MJJ09_RS12485 (MJJ09_12450)	2646825..2648009	-	1185	WP_011408397.1	IS256-like element IS1113 family transposase	-
MJJ09_RS12490 (MJJ09_12455)	2648590..2649555	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
MJJ09_RS12495 (MJJ09_12460)	2649705..2650262	+	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T236015 WP_229001948.1 NZ_CP092380:c2645074-2644823 [Xanthomonas oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T236015 NZ_LR135174:214275-214541 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT236015 WP_011408759.1 NZ_CP092380:c2645379-2645101 [Xanthomonas oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT236015 NZ_LR135174:214012-214275 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2