Detailed information of TA system TA236006

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 3421524..3422098
• Replicon: chromosome
• Accession: NZ_CP092373
• Organism: Pantoea sp. Z09

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MC269_RS16340
• Protein ID: WP_201789473.1
• Coordinates: 3421524..3421853 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: MC269_RS16345
• Protein ID: WP_239953047.1
• Coordinates: 3421847..3422098 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC269_RS16330	3417249..3417467	+	219	WP_081136904.1	MbtH family protein	-
MC269_RS16335	3417460..3421380	+	3921	WP_239953046.1	enterobactin synthase subunit F	-
MC269_RS16340	3421524..3421853	-	330	WP_201789473.1	endoribonuclease MazF	Toxin
MC269_RS16345	3421847..3422098	-	252	WP_239953047.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
MC269_RS16350	3422406..3423206	-	801	WP_239953048.1	ATP-binding cassette domain-containing protein	-
MC269_RS16355	3423203..3424183	-	981	WP_239953049.1	iron-enterobactin ABC transporter permease	-
MC269_RS16360	3424180..3425169	-	990	WP_239953050.1	Fe(3+)-siderophore ABC transporter permease	-
MC269_RS16365	3425314..3426564	+	1251	WP_239953051.1	enterobactin transporter EntS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (9-103)

Antitoxin

• SpoVT-AbrB domain (6-39)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 11797.81 Da
• Isoelectric Point: 10.4524

>T236006 WP_201789473.1 NZ_CP092373:c3421853-3421524 [Pantoea sp. Z09]
MVMQSVPDAGDILWLDFTPQAGHEQAGRRPALVMSPAIYNRIGMMVCVPLTTRIKGNPFEVPIAGAPANVALADQVRNLD
WKARNAAPKGRATPQELEAVRVKARLLIG

Nucleotide

• Length: 330 bp

>T236006 NZ_LR134536:c1942215-1941853 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9510.82 Da
• Isoelectric Point: 4.3000

>AT236006 WP_239953047.1 NZ_CP092373:c3422098-3421847 [Pantoea sp. Z09]
MRQTIKRWGNSPAVRIPAHMMSLMNMDINEEVEVTVQTDSNNVQCLVIQPVRQVTLEMLMSQVTPENIHSETDFGDPQGQ
EVW

Nucleotide

• Length: 252 bp

>AT236006 NZ_LR134536:c1942382-1942212 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA