Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 3373066..3373655 Replicon chromosome
Accession NZ_CP092373
Organism Pantoea sp. Z09

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MC269_RS16105 Protein ID WP_239953018.1
Coordinates 3373323..3373655 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MC269_RS16100 Protein ID WP_239953017.1
Coordinates 3373066..3373323 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC269_RS16090 3369613..3370071 + 459 WP_081136856.1 DNA polymerase III subunit chi -
MC269_RS16095 3370077..3372932 + 2856 WP_081136858.1 valine--tRNA ligase -
MC269_RS16100 3373066..3373323 + 258 WP_239953017.1 antitoxin Antitoxin
MC269_RS16105 3373323..3373655 + 333 WP_239953018.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MC269_RS16110 3373673..3374899 - 1227 WP_239953019.1 hypothetical protein -
MC269_RS16115 3374996..3375499 + 504 WP_239953020.1 GNAT family N-acetyltransferase -
MC269_RS16120 3375514..3376275 - 762 WP_239953021.1 tRNA isopentenyl-2-thiomethyl-A-37 hydroxylase MiaE -
MC269_RS16125 3376331..3376762 - 432 WP_239953022.1 ribonuclease E inhibitor RraB -
MC269_RS16130 3376926..3377933 + 1008 WP_239953023.1 ornithine carbamoyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11940.75 Da        Isoelectric Point: 9.6313

>T236005 WP_239953018.1 NZ_CP092373:3373323-3373655 [Pantoea sp. Z09]
MERGEIWLVSLDPTAGHEQQGTRPVLIVSPAAFNQLTQTPVVLPVTTGGNFARTAGFTVSLDTAGTRTRGVIRCDQPRAI
DMRARHGKRLEHIPADLMAEVQAILRAILS

Download         Length: 333 bp

>T236005 NZ_LR134536:c1813434-1813039 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9158.64 Da        Isoelectric Point: 4.3843

>AT236005 WP_239953017.1 NZ_CP092373:3373066-3373323 [Pantoea sp. Z09]
MHTTHLRKVGGSVMLAVPPALLDILQLSADAQVGLTVDNGRLIIEPKTVPSYTLAELLAKCDPEAELTAEDRLWIDAVPV
GKEEL

Download         Length: 258 bp

>AT236005 NZ_LR134536:c1813664-1813434 [Staphylococcus epidermidis]
ATGATTACTACAAGAAAACTAAGAAAAGCTGGTAATAGTTCAGTTGTTTCTGTACCGACAGAAGTGATCGCAGCACTCGG
AATATCAAATGGTGATAATCTTAAATTTAATGTAAAAGATAATAAAGTAACCATCGAAAAGGAGGTAAGAGAGGACGAGG
AGTTTTTTAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTTTAAAAAGGATGGTTGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References