Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2871338..2871957 Replicon chromosome
Accession NZ_CP092373
Organism Pantoea sp. Z09

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag MC269_RS13835 Protein ID WP_081139327.1
Coordinates 2871739..2871957 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag MC269_RS13830 Protein ID WP_081139328.1
Coordinates 2871338..2871715 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC269_RS13800 2867656..2867916 + 261 WP_239952756.1 type B 50S ribosomal protein L31 -
MC269_RS13805 2867919..2868059 + 141 WP_071997379.1 type B 50S ribosomal protein L36 -
MC269_RS13810 2868102..2868980 - 879 WP_081139332.1 metal ABC transporter substrate-binding protein -
MC269_RS13815 2868993..2869832 - 840 WP_081139331.1 metal ABC transporter permease -
MC269_RS13820 2869829..2870488 - 660 WP_239952757.1 ATP-binding cassette domain-containing protein -
MC269_RS13825 2870837..2870998 + 162 WP_239952758.1 hypothetical protein -
MC269_RS13830 2871338..2871715 + 378 WP_081139328.1 Hha toxicity modulator TomB Antitoxin
MC269_RS13835 2871739..2871957 + 219 WP_081139327.1 HHA domain-containing protein Toxin
MC269_RS13845 2872344..2872655 + 312 WP_239952759.1 MGMT family protein -
MC269_RS13850 2872689..2873246 - 558 WP_239952760.1 YbaY family lipoprotein -
MC269_RS13855 2873436..2874299 + 864 WP_239952761.1 acyl-CoA thioesterase II -
MC269_RS13860 2874391..2875677 - 1287 WP_081139323.1 ammonium transporter AmtB -
MC269_RS13865 2875711..2876049 - 339 WP_033752690.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8632.01 Da        Isoelectric Point: 8.9007

>T236004 WP_081139327.1 NZ_CP092373:2871739-2871957 [Pantoea sp. Z09]
MNDKMLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPGSVWKFVR

Download         Length: 219 bp

>T236004 NZ_LR134536:c1610995-1610816 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14665.25 Da        Isoelectric Point: 4.3976

>AT236004 WP_081139328.1 NZ_CP092373:2871338-2871715 [Pantoea sp. Z09]
MDEYSPKRHDIAQLKFLCESLFDESMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHAEDEALITQIDDYL
DDTFMLFTNYGINAQDLNRWQRSARRLFNIFSEECAYLQQPSHSI

Download         Length: 378 bp

>AT236004 NZ_LR134536:c1611618-1611019 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References