Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1505775..1506556 Replicon chromosome
Accession NZ_CP092373
Organism Pantoea sp. Z09

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag MC269_RS07135 Protein ID WP_239954648.1
Coordinates 1506065..1506556 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag MC269_RS07130 Protein ID WP_239954647.1
Coordinates 1505775..1506068 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC269_RS07105 1500903..1502312 + 1410 WP_239955087.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
MC269_RS07110 1502429..1502593 + 165 WP_239954642.1 hypothetical protein -
MC269_RS07115 1502752..1504341 + 1590 WP_239954643.1 DNA/RNA non-specific endonuclease -
MC269_RS07120 1504352..1504543 + 192 WP_239954645.1 hypothetical protein -
MC269_RS07125 1504744..1505601 + 858 WP_239954646.1 glucose 1-dehydrogenase -
MC269_RS07130 1505775..1506068 + 294 WP_239954647.1 DUF1778 domain-containing protein Antitoxin
MC269_RS07135 1506065..1506556 + 492 WP_239954648.1 GNAT family N-acetyltransferase Toxin
MC269_RS07145 1506797..1507573 - 777 WP_239954649.1 DgsA anti-repressor MtfA -
MC269_RS07150 1507735..1508412 - 678 WP_239954650.1 hypothetical protein -
MC269_RS07155 1509011..1509709 + 699 WP_239954651.1 phosphohydrolase -
MC269_RS07160 1509788..1510039 + 252 WP_239954653.1 Arc family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17679.67 Da        Isoelectric Point: 8.5113

>T235995 WP_239954648.1 NZ_CP092373:1506065-1506556 [Pantoea sp. Z09]
VISAPEPLHADHGLSLFCCGVESMDNWLKQRAMKNQLTGASRTFVCCDGANVLAYYSLASSAVVTSVAPGRFRRNMPDPI
PVVVLGRLAVDKRIQGQGVARALVRDAGLRVIQASDTIGIRGMLVHALSDEARRFYLRIGFEPSPIDPMVLMVTLGDVMQ
TLL

Download         Length: 492 bp

>T235995 NZ_LR134533:c2145162-2145040 [Neisseria weaveri]
ATGAAAAAATTAGCTTTAATCACAATTGCTACCGTAGCATTGCTAACCGGCTGCAACACCATTGCCGGTGCAGGTAAAGA
TGTCAGCGCAGTAGGACGCGCTGTTACCCATGTTGCCCAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10923.49 Da        Isoelectric Point: 10.0803

>AT235995 WP_239954647.1 NZ_CP092373:1505775-1506068 [Pantoea sp. Z09]
MPAPDSFSVKRETLNLRIRPAERDLIDRAAKAKGKNRTDFVLDAARAAAEDALIEQRVMLVDPDGWQAFITRLDQPPAPN
AELRRTMQTPAPWDAKK

Download         Length: 294 bp

>AT235995 NZ_LR134533:c2145009-2144869 [Neisseria weaveri]
ATGAAAAAATTCGCACTGATCGCTCTTACCGCCGTTTCTTTCTTGGCCGGTTGCAATACCATTGCCGGCGCAGGTAAAGA
TGTCAGCGCTGCAGGTAACGCTGTAACCAACACGGCACAAGACGTTAAATCTGCTATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References