Detailed information of TA system TA235995

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1505775..1506556
• Replicon: chromosome
• Accession: NZ_CP092373
• Organism: Pantoea sp. Z09

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: MC269_RS07135
• Protein ID: WP_239954648.1
• Coordinates: 1506065..1506556 (+)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: MC269_RS07130
• Protein ID: WP_239954647.1
• Coordinates: 1505775..1506068 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC269_RS07105	1500903..1502312	+	1410	WP_239955087.1	EmmdR/YeeO family multidrug/toxin efflux MATE transporter	-
MC269_RS07110	1502429..1502593	+	165	WP_239954642.1	hypothetical protein	-
MC269_RS07115	1502752..1504341	+	1590	WP_239954643.1	DNA/RNA non-specific endonuclease	-
MC269_RS07120	1504352..1504543	+	192	WP_239954645.1	hypothetical protein	-
MC269_RS07125	1504744..1505601	+	858	WP_239954646.1	glucose 1-dehydrogenase	-
MC269_RS07130	1505775..1506068	+	294	WP_239954647.1	DUF1778 domain-containing protein	Antitoxin
MC269_RS07135	1506065..1506556	+	492	WP_239954648.1	GNAT family N-acetyltransferase	Toxin
MC269_RS07145	1506797..1507573	-	777	WP_239954649.1	DgsA anti-repressor MtfA	-
MC269_RS07150	1507735..1508412	-	678	WP_239954650.1	hypothetical protein	-
MC269_RS07155	1509011..1509709	+	699	WP_239954651.1	phosphohydrolase	-
MC269_RS07160	1509788..1510039	+	252	WP_239954653.1	Arc family DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (68-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-94)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17679.67 Da
• Isoelectric Point: 8.5113

>T235995 WP_239954648.1 NZ_CP092373:1506065-1506556 [Pantoea sp. Z09]
VISAPEPLHADHGLSLFCCGVESMDNWLKQRAMKNQLTGASRTFVCCDGANVLAYYSLASSAVVTSVAPGRFRRNMPDPI
PVVVLGRLAVDKRIQGQGVARALVRDAGLRVIQASDTIGIRGMLVHALSDEARRFYLRIGFEPSPIDPMVLMVTLGDVMQ
TLL

Nucleotide

• Length: 492 bp

>T235995 NZ_LR134533:c2145162-2145040 [Neisseria weaveri]
ATGAAAAAATTAGCTTTAATCACAATTGCTACCGTAGCATTGCTAACCGGCTGCAACACCATTGCCGGTGCAGGTAAAGA
TGTCAGCGCAGTAGGACGCGCTGTTACCCATGTTGCCCAATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10923.49 Da
• Isoelectric Point: 10.0803

>AT235995 WP_239954647.1 NZ_CP092373:1505775-1506068 [Pantoea sp. Z09]
MPAPDSFSVKRETLNLRIRPAERDLIDRAAKAKGKNRTDFVLDAARAAAEDALIEQRVMLVDPDGWQAFITRLDQPPAPN
AELRRTMQTPAPWDAKK

Nucleotide

• Length: 294 bp

>AT235995 NZ_LR134533:c2145009-2144869 [Neisseria weaveri]
ATGAAAAAATTCGCACTGATCGCTCTTACCGCCGTTTCTTTCTTGGCCGGTTGCAATACCATTGCCGGCGCAGGTAAAGA
TGTCAGCGCTGCAGGTAACGCTGTAACCAACACGGCACAAGACGTTAAATCTGCTATGTAA