Detailed information of TA system TA235993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1286342..1286973
• Replicon: chromosome
• Accession: NZ_CP092373
• Organism: Pantoea sp. Z09

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MC269_RS06165
• Protein ID: WP_239955079.1
• Coordinates: 1286342..1286740 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MC269_RS06170
• Protein ID: WP_239954451.1
• Coordinates: 1286740..1286973 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC269_RS06145	1281346..1282704	-	1359	WP_239955078.1	tRNA 5-hydroxyuridine modification protein YegQ	-
MC269_RS06150	1282822..1283529	-	708	WP_239954448.1	two-component system response regulator BaeR	-
MC269_RS06155	1283536..1284924	-	1389	WP_239954449.1	two-component system sensor histidine kinase BaeS	-
MC269_RS06160	1284921..1286327	-	1407	WP_239954450.1	multidrug transporter subunit MdtD	-
MC269_RS06165	1286342..1286740	-	399	WP_239955079.1	type II toxin-antitoxin system VapC family toxin	Toxin
MC269_RS06170	1286740..1286973	-	234	WP_239954451.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MC269_RS06175	1287040..1290111	-	3072	WP_239954452.1	multidrug efflux RND transporter permease subunit MdtC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-55)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15113.40 Da
• Isoelectric Point: 9.3346

>T235993 WP_239955079.1 NZ_CP092373:c1286740-1286342 [Pantoea sp. Z09]
MHRYMLDTNIVIYVIKRRPIEMLSKFNAQLGRMVISSITLAELYYGAEKSQFPDRNLRVVEDFVSRLDVLSYDARAAFHY
GAIRADLERKGTPVGANDLHIAAHARSMGLTLVSNNLREFNRVEGLLSENWL

Nucleotide

• Length: 399 bp

>T235993 NZ_LR134533:1140215-1140616 [Neisseria weaveri]
ATGCTTCGCTATATGCTTGATATCAATATCTGCATTTACACGATTAAAAACAATCCCGCAGCAGTGCGCGAAAAGTTCCA
ACAACATCAGCATCATATGTGTATCAGCAGCATTGTGCTGACCGAGCTGCTGTATGGTGCTGAAAAATCAAGCAATCCGG
CCAAATCTCTAGCCTTAATTGAAGGTATGGCGGCACGATTGGAAGTATTGAATTTTGATGAAACTGCTGCTGCCCATGCT
GCTGAAATCCGTGCTGATCTTGCCCGGAAAGGCACGCCAATCGGACACTATGATGTTCTGATTGCCGGCCATGCCCGCAG
CCGCGGTTTGATATTGGTCAGCAATAATCTGCGGGAATTTGAGCGGGTAGCGGGGTTAAGGTTGGAGAACTGGGCAGTTT
GA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8707.67 Da
• Isoelectric Point: 4.5183

>AT235993 WP_239954451.1 NZ_CP092373:c1286973-1286740 [Pantoea sp. Z09]
MSQGTIFTSNRTQNVRIPADVRFPENVKNVTVRAVGNERIIAPVEHAWDSFFLSEQCVSDDFLSERTTPPADEREAL

Nucleotide

• Length: 234 bp

>AT235993 NZ_LR134533:1139988-1140212 [Neisseria weaveri]
ATGGCTCAAGCGACTCTTTTTAAAAGCAATCAAACCCAAGCCGTGCGTCTGCCTAAAGCCGTAGCTTTTCCCGATGATGT
GAAAAAAGTGGAGGTGGTCGTATTGGGAAAATCGCGCCTGCTCACGCCCAGTGAAAACTTATGGGACGATTGGTTTGCAC
AATTGCCGCAAGCCGACTTTCCCGACCGCGAGCCTAGTTTTCAAGCCGAGCGGGAGAGTTTCTAA