Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 717657..718306 Replicon chromosome
Accession NC_012207
Organism Mycobacterium bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag JTY_RS03275 Protein ID WP_003403236.1
Coordinates 717911..718306 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag JTY_RS03270 Protein ID WP_003403235.1
Coordinates 717657..717911 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTY_RS22195 712782..712865 + 84 Protein_640 galactose-1-phosphate uridylyltransferase -
JTY_RS03245 712884..713966 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
JTY_RS03250 713963..715054 + 1092 WP_003403225.1 galactokinase -
JTY_RS03260 715449..716606 + 1158 WP_003903091.1 hypothetical protein -
JTY_RS03265 716617..717564 + 948 WP_003403232.1 DUF732 domain-containing protein -
JTY_RS03270 717657..717911 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
JTY_RS03275 717911..718306 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
JTY_RS03280 718400..719140 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
JTY_RS03285 719272..719532 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JTY_RS03290 719529..719936 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
JTY_RS03295 720008..721159 - 1152 WP_003403248.1 FIST C-terminal domain-containing protein -
JTY_RS03300 721252..722979 - 1728 WP_010950423.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T23597 WP_003403236.1 NC_012207:717911-718306 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T23597 NC_012207:717911-718306 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT23597 WP_003403235.1 NC_012207:717657-717911 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT23597 NC_012207:717657-717911 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References