Detailed information of TA system TA235967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-PHD
• Location: 4183482..4184107
• Replicon: chromosome
• Accession: NZ_CP092364
• Organism: Mycolicibacterium goodii strain ATCC 700504

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MI170_RS20010
• Protein ID: WP_073680646.1
• Coordinates: 4183482..4183862 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MI170_RS20015
• Protein ID: WP_073680647.1
• Coordinates: 4183859..4184107 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MI170_RS19970 (MI170_07855)	4178724..4179446	+	723	WP_240174388.1	SDR family oxidoreductase	-
MI170_RS19975 (MI170_07850)	4179459..4179869	+	411	WP_100516622.1	cupin domain-containing protein	-
MI170_RS19980 (MI170_07845)	4179921..4180211	+	291	WP_214314008.1	hypothetical protein	-
MI170_RS19985 (MI170_07840)	4180218..4181285	+	1068	WP_240174387.1	C40 family peptidase	-
MI170_RS19990 (MI170_07835)	4181282..4181476	+	195	WP_073680644.1	hypothetical protein	-
MI170_RS19995 (MI170_07830)	4181512..4182789	+	1278	WP_214314005.1	primosomal protein	-
MI170_RS20000 (MI170_07825)	4182671..4183156	-	486	WP_235716466.1	zinc ribbon domain-containing protein	-
MI170_RS20005 (MI170_07820)	4183214..4183369	-	156	WP_214385591.1	hypothetical protein	-
MI170_RS20010 (MI170_07815)	4183482..4183862	-	381	WP_073680646.1	type II toxin-antitoxin system VapC family toxin	Toxin
MI170_RS20015 (MI170_07810)	4183859..4184107	-	249	WP_073680647.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MI170_RS20020 (MI170_07805)	4184875..4186323	+	1449	WP_235717604.1	cytosine permease	-
MI170_RS20025 (MI170_07800)	4186496..4187767	+	1272	WP_073680672.1	NAD(P)/FAD-dependent oxidoreductase	-
MI170_RS20030 (MI170_07795)	4187764..4188186	+	423	WP_100516613.1	RidA family protein	-
MI170_RS20035 (MI170_07790)	4188183..4188857	+	675	WP_073680649.1	DUF1028 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-110)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13359.41 Da
• Isoelectric Point: 6.4686

>T235967 WP_073680646.1 NZ_CP092364:c4183862-4183482 [Mycolicibacterium goodii]
VRALLDTSVIIATDVGPLEGELAISAITVAEMHFGVLVAKTPEIRAERLRRLLALQRTFDALPVDNAVADSYGPVAAAIA
RAGRQPRARSMDLLIAATARAHSARLYTRNAADFAGLDDLVDVVAV

Nucleotide

• Length: 381 bp

>T235967 NZ_LR134519:c1063657-1063391 [Helicobacter pylori]
GTGTTAAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAAGTCATTCTAACCTTAAGAAAGAAAGAACCACTACCCCCACCCTTTAAAGATCATGCCTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATTAAGCCTGATGTTTTGCTTGTGTATTTAGTGAAAGATAATGAGCTTATTTTGTTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9317.22 Da
• Isoelectric Point: 4.3837

>AT235967 WP_073680647.1 NZ_CP092364:c4184107-4183859 [Mycolicibacterium goodii]
MENVGLRELRQDASDLVRRVEQGEEFTITVAGRPSARLVSATPRAWRTWADVAGVFRGPADPDWDADRDTVDQELHDPWE
AR

Nucleotide

• Length: 249 bp

>AT235967 NZ_LR134519:c1064012-1063638 [Helicobacter pylori]
ATGCCTAACACCACCAACAAAGATTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCGAAA
AATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACTTTA
AGGATAAAATAGACGCATTAAAGGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTGGGG
CATGAGATCCCAAACCTTCAAACGCAACAAGCCATAAGAGATGCGCTCAACAAAGAAACCGATTTGATTGTTGAGGATTT
TTCTAGTTACAGCGATGAAAGAAAAAAGGCGTTAGGTGTTAAAACTCAATCTTAA