Detailed information of TA system TA235966

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2371435..2372431
• Replicon: chromosome
• Accession: NZ_CP092364
• Organism: Mycolicibacterium goodii strain ATCC 700504

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: MI170_RS11345
• Protein ID: WP_214312736.1
• Coordinates: 2371435..2372013 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: MI170_RS11350
• Protein ID: WP_073680854.1
• Coordinates: 2372039..2372431 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MI170_RS11325 (MI170_16490)	2367397..2367957	+	561	WP_073680869.1	hypothetical protein	-
MI170_RS11330 (MI170_16485)	2367984..2369372	-	1389	WP_214312737.1	L-serine ammonia-lyase	-
MI170_RS11335 (MI170_16480)	2369606..2369761	-	156	WP_100516311.1	hypothetical protein	-
MI170_RS11340 (MI170_16475)	2370071..2371423	+	1353	WP_073680852.1	alpha/beta hydrolase-fold protein	-
MI170_RS11345 (MI170_16470)	2371435..2372013	-	579	WP_214312736.1	zeta toxin family protein	Toxin
MI170_RS11350 (MI170_16465)	2372039..2372431	-	393	WP_073680854.1	hypothetical protein	Antitoxin
MI170_RS11355 (MI170_16460)	2372495..2373124	-	630	WP_073680870.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
MI170_RS11360 (MI170_16455)	2373390..2375009	+	1620	WP_214312735.1	GMC family oxidoreductase N-terminal domain-containing protein	-
MI170_RS11365 (MI170_16450)	2375023..2375628	-	606	WP_100516310.1	class I SAM-dependent methyltransferase	-
MI170_RS11370 (MI170_16445)	2375730..2376857	-	1128	WP_240173042.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-142)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21035.97 Da
• Isoelectric Point: 7.6109

>T235966 WP_214312736.1 NZ_CP092364:c2372013-2371435 [Mycolicibacterium goodii]
VKRLDLVVGSNGAGKSTFVELTLAPLLPGSSFVNADEIAKRRWPDAPAQHAYEAARIAADTRHKLIELGESFIAETVFSH
PSKLELVDTAQAAGYTVVLHAVMIPEDLAVLRVQHRVRAGGHHVPEDKIRERYQRLWPLVATAATHADIATFYDNSAVEG
PRMVAQLTGGFVVGSATWPAWTPRVLRSRWAD

Nucleotide

• Length: 579 bp

>T235966 NZ_LR134519:c1063657-1063391 [Helicobacter pylori]
GTGTTAAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAAGTCATTCTAACCTTAAGAAAGAAAGAACCACTACCCCCACCCTTTAAAGATCATGCCTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATTAAGCCTGATGTTTTGCTTGTGTATTTAGTGAAAGATAATGAGCTTATTTTGTTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 13839.31 Da
• Isoelectric Point: 5.2305

>AT235966 WP_073680854.1 NZ_CP092364:c2372431-2372039 [Mycolicibacterium goodii]
MTETADRVTRFAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTAARRRVEAALAGDLALRDLTSEEGVVFNAEI
SAAIEEGLAHTDYGKVLAARGVTTVALDDSGEIVRYEPDGTTTALTSKLR

Nucleotide

• Length: 393 bp

>AT235966 NZ_LR134519:c1063330-1062938 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTGTTTG
GGGCATGAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGTTAAATGGGGTTAATCTCACTCAAATTGATAG
TTTAGATGATCTTACAAACGAGTTAAAAAGAGAAAATAATAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA