Detailed information of TA system TA235964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 106835..107396
• Replicon: plasmid unnamed
• Accession: NZ_CP092363
• Organism: Mycolicibacterium crocinum strain JCM 16369

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MI149_RS29780
• Protein ID: WP_240180777.1
• Coordinates: 106835..107113 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MI149_RS29785
• Protein ID: WP_240180776.1
• Coordinates: 107115..107396 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MI149_RS29755 (MI149_29525)	102187..102511	-	325	Protein_103	isoprenylcysteine carboxylmethyltransferase family protein	-
MI149_RS29760 (MI149_29520)	102630..103234	+	605	Protein_104	HAD-IC family P-type ATPase	-
MI149_RS29765 (MI149_29515)	103348..104565	-	1218	WP_240180779.1	hypothetical protein	-
MI149_RS29770 (MI149_29510)	104667..105923	-	1257	WP_240176145.1	IS256 family transposase	-
MI149_RS29775 (MI149_29505)	106045..106437	-	393	WP_240180778.1	hypothetical protein	-
MI149_RS29780 (MI149_29500)	106835..107113	-	279	WP_240180777.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MI149_RS29785 (MI149_29495)	107115..107396	-	282	WP_240180776.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MI149_RS29790 (MI149_29490)	108624..109907	+	1284	WP_051660572.1	hypothetical protein	-
MI149_RS29795 (MI149_29485)	109904..111037	+	1134	WP_036349192.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..199256	199256
	-	flank	IS/Tn	-	-	104667..106028	1361

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (10-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10521.01 Da
• Isoelectric Point: 11.0415

>T235964 WP_240180777.1 NZ_CP092363:c107113-106835 [Mycolicibacterium crocinum]
VNAEDGYTTRFTATARRDLDKLPPRILAAVIEFAFGDLTREPRRVGKPLGGKLAGQFSARRGPYRLLYRIDDPAATIWVH
RVDHRSDVYRRP

Nucleotide

• Length: 279 bp

>T235964 NZ_LR134517:c860506-860222 [Helicobacter pylori]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAATGGACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCGCAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTGGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10367.59 Da
• Isoelectric Point: 4.4805

>AT235964 WP_240180776.1 NZ_CP092363:c107396-107115 [Mycolicibacterium crocinum]
MRILPISQLKSKINEYVDAVSDTRDQITITKNGAPAAVLIGVDEWESIQETLHWLSQPGIVESVSESESDIAAGRTYGED
EIRAAYQVPRRPR

Nucleotide

• Length: 282 bp

>AT235964 NZ_LR134517:c860744-860487 [Helicobacter pylori]
ATGGCTAAAGAGCTAGAAAAAAAAGATAAAGGTTTCACTATCAAATTAGAAGAGTTGAACAAAATCTTACAAGAGATCAA
CAAAAGAGCTAATGATTGTTGTTTTGGGCATGAAACCCCAAACATTGAAACGCAACAAGCCATGAGAGAAGCGTTAAATG
GAATTAATCTCACTCAAATTGATAGTTTAGATGATTTTACAAACGAGTTAAAAAGAGAAAATAGTAAAGGTTTTGAAAAT
GTATGCTTTAGCGTTTGA