Detailed information of TA system TA235962

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 2970591..2971252
• Replicon: chromosome
• Accession: NZ_CP092362
• Organism: Mycolicibacterium crocinum strain JCM 16369

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MI149_RS14535
• Protein ID: WP_240180268.1
• Coordinates: 2970591..2970989 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MI149_RS14540
• Protein ID: WP_240180269.1
• Coordinates: 2970986..2971252 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MI149_RS14515 (MI149_14500)	2967121..2967486	+	366	WP_071945079.1	nitrite reductase small subunit NirD	-
MI149_RS14520 (MI149_14505)	2967458..2968603	+	1146	WP_240180265.1	uroporphyrinogen-III synthase	-
MI149_RS14525 (MI149_14510)	2968600..2969277	+	678	WP_240180266.1	sirohydrochlorin chelatase	-
MI149_RS14530 (MI149_14515)	2969307..2970587	+	1281	WP_240180267.1	threonine ammonia-lyase IlvA	-
MI149_RS14535 (MI149_14520)	2970591..2970989	-	399	WP_240180268.1	type II toxin-antitoxin system VapC family toxin	Toxin
MI149_RS14540 (MI149_14525)	2970986..2971252	-	267	WP_240180269.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MI149_RS14545 (MI149_14530)	2971270..2971596	-	327	WP_240180270.1	hypothetical protein	-
MI149_RS14550 (MI149_14535)	2971824..2973548	-	1725	WP_240180271.1	malto-oligosyltrehalose trehalohydrolase	-
MI149_RS14555 (MI149_14540)	2973541..2975844	-	2304	WP_240180272.1	malto-oligosyltrehalose synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-47)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14318.63 Da
• Isoelectric Point: 7.2013

>T235962 WP_240180268.1 NZ_CP092362:c2970989-2970591 [Mycolicibacterium crocinum]
MMQVYLDTSALMKLVVLEPETSALRTYLTQYPDDVRFTAALSRTELLRAARRSGSYELAAQAHRLLGRLDLVAMTTRLLD
EAGTLGPPELRTLDAIHLAAARTAPALRGLVTYDLRLAAAAEAVGITVAIPQ

Nucleotide

• Length: 399 bp

>T235962 NZ_LR134516:1419406-1419657 [Neisseria animaloris]
ATGAAAAAACACCAGCGGACACTTGCCTCGATATTCAGCCGCCCCGTATCCGGCAGCATCAAATGGGCGGATATTGAAGC
TCTGTTTATCGAATTGGACGCGGAAATTCAAGAGAGGGAGGGCAGCCGTATAGCGGTAATCCTTTTCGGACAAGTGAAAG
TGTTCCATAGGCCGCATCCAAGCCCTGATACGGATAAAGGCGCGGTTGCGAGCGTGCGGAAATGGTTGGAAGAAAACGGA
GTAAAGCCATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9911.17 Da
• Isoelectric Point: 4.8892

>AT235962 WP_240180269.1 NZ_CP092362:c2971252-2970986 [Mycolicibacterium crocinum]
MERIGLRELRQHASQYVDRAAGGESIEITVRGRLVAMLVPAGEGTWDDLIVRGEVLPAPARLDLLDEPARDYGFDASESL
RRLRDHER

Nucleotide

• Length: 267 bp

>AT235962 NZ_LR134516:1419654-1419989 [Neisseria animaloris]
ATGAACAATGTAATGGAAATCAACGGCCATAAAGCCATTATTCAATACGACCCTGAAACCGAGTTGCTACGCGGCGAGTT
TATCGGCCTCAACGGCGGGGCGGATTTTTACGCCGATAACGTGGCAGACTTGCACAAAGAGGGAGCGGCAAGCCTGGCAG
TTTTTCTCGATGTGTGCAAAGAAAAAGGTATTGAGCCGTATAAACAGTATTCGGGTCGCTTCAATGTGCGGGTAAGCCCT
GAAACCCATGCGGCAGCGGCGGCTGCTGCGGCCTCTCAAAATATCAGCCTTAACGAGTGGGTAAACCGCGCCATCCGACA
ATGTGCCCATGGCTGA