Detailed information of TA system TA235961

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1058942..1059600
• Replicon: chromosome
• Accession: NZ_CP092362
• Organism: Mycolicibacterium crocinum strain JCM 16369

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MI149_RS05075
• Protein ID: WP_240178912.1
• Coordinates: 1059202..1059600 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MI149_RS05070
• Protein ID: WP_240178911.1
• Coordinates: 1058942..1059205 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MI149_RS05035 (MI149_05015)	1054578..1055003	+	426	WP_240178905.1	cupin domain-containing protein	-
MI149_RS05040 (MI149_05020)	1055060..1055275	-	216	WP_240178906.1	DUF4926 domain-containing protein	-
MI149_RS05045 (MI149_05025)	1055289..1056104	-	816	WP_262871740.1	hypothetical protein	-
MI149_RS05050 (MI149_05030)	1056635..1056922	-	288	WP_240178908.1	WXG100 family type VII secretion target	-
MI149_RS05055 (MI149_05035)	1056919..1057236	-	318	WP_240178909.1	WXG100 family type VII secretion target	-
MI149_RS05060 (MI149_05040)	1057402..1057977	+	576	WP_240180295.1	hypothetical protein	-
MI149_RS05065 (MI149_05045)	1058001..1058906	+	906	WP_240178910.1	hypothetical protein	-
MI149_RS05070 (MI149_05050)	1058942..1059205	+	264	WP_240178911.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MI149_RS05075 (MI149_05055)	1059202..1059600	+	399	WP_240178912.1	type II toxin-antitoxin system VapC family toxin	Toxin
MI149_RS05080 (MI149_05060)	1059642..1061300	+	1659	WP_240178913.1	hypothetical protein	-
MI149_RS05085 (MI149_05065)	1061307..1061789	-	483	WP_240178914.1	hypothetical protein	-
MI149_RS05090 (MI149_05070)	1061890..1062699	+	810	WP_240178915.1	glycoside hydrolase family 16 protein	-
MI149_RS05095 (MI149_05075)	1062882..1064099	-	1218	WP_262871741.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1048949..1059600	10651

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-86)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14227.17 Da
• Isoelectric Point: 4.6075

>T235961 WP_240178912.1 NZ_CP092362:1059202-1059600 [Mycolicibacterium crocinum]
VIVDTSAIVAIALNEPERDRLVDALVDAAEPKISAATLVEVSAVLLRRLKPEDLRRVERLIDQLRIVTVPFDAEQAANAT
RAYREFGRGSGHRAGLNLGDCYSYALAAVTGEPLLFVGDDFTHTDITPAALG

Nucleotide

• Length: 399 bp

>T235961 NZ_LR134516:c919749-919354 [Neisseria animaloris]
ATGCGCTACCTTTTGGATACCAACATTGTGAGCCATATCCTGCGCCGTCAGCCGAATGTGATGGCAAAATTGCAAAGCGT
GCCGATGTCTGATCTACATATTTCGGCGGTTACTCATGCCGAATTGATGTACGGCTTGGCGAAAAAACCTGATGCGGCCA
AGCTGCATCGTGCCGTGCATGAACTTTTATTGCGTATAAGCGTATTGCCGTTCGACGAACAAGCAAGCACGCATTACGGA
AAATTTAAAGCACAGGCAGAGCAGTCGGGTAAAAACCTGGCATCTTTAGATATGATGATTGCCGCCCATGCTTCCGCCGT
AAGCGCAGTATTGGTCAGCAACGATGCAGCTTTCCAACAGATTGCTGATTTATCGGTGGAAGACTGGACAAAATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9614.78 Da
• Isoelectric Point: 8.6819

>AT235961 WP_240178911.1 NZ_CP092362:1058942-1059205 [Mycolicibacterium crocinum]
MSLNIKNPQTVALVRELARRTGLSQTSAVEEAVRARLAQVTAGEGGDTRRQKVDDLLAELDRSITAHQRKSIRKDQTDLY
DENGLPA

Nucleotide

• Length: 264 bp

>AT235961 NZ_LR134516:c919998-919753 [Neisseria animaloris]
ATGCAAACCGCCAAACTTTTTCAAAACGGCCGTAGTCAAGCCGTGCGGCTGCCTGCTGCATTCCGATTTACGGGTGATGA
AGTGTATATCCGCCGAGACGAAGCCACGGGCGATGTGATTCTGTCGCAACGTCCGAGCGACTGGCAGGGTTTTATCGCCG
CAGCATCGGAGCTTGACGAAAGCGATACCATTGAACGCGATACCTCCATACAACAACGCGATCCCTTTGCAGACTGGCAG
GAATAA