235959

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1894146..1894619 Replicon chromosome
Accession NZ_CP092361
Organism Wielerella bovis strain CCUG 44465

Toxin (Protein)


Gene name VapD Uniprot ID -
Locus tag MIS45_RS09235 Protein ID WP_249450314.1
Coordinates 1894341..1894619 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID -
Locus tag MIS45_RS09230 Protein ID WP_249450313.1
Coordinates 1894146..1894337 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIS45_RS09205 (MIS45_09205) 1889485..1890951 + 1467 WP_249450308.1 DegQ family serine endoprotease -
MIS45_RS09210 (MIS45_09210) 1891053..1891871 - 819 WP_249450309.1 transporter substrate-binding domain-containing protein -
MIS45_RS09215 (MIS45_09215) 1892373..1892648 + 276 WP_249448426.1 DUF493 family protein -
MIS45_RS09220 (MIS45_09220) 1892716..1893318 + 603 WP_249450310.1 lipoyl(octanoyl) transferase LipB -
MIS45_RS09225 (MIS45_09225) 1893371..1894096 + 726 WP_249450311.1 SDR family NAD(P)-dependent oxidoreductase -
MIS45_RS09230 (MIS45_09230) 1894146..1894337 + 192 WP_249450313.1 DUF5397 family protein Antitoxin
MIS45_RS09235 (MIS45_09235) 1894341..1894619 + 279 WP_249450314.1 virulence factor Toxin
MIS45_RS09240 (MIS45_09240) 1894657..1895643 + 987 WP_249450315.1 lipoyl synthase -
MIS45_RS11415 1895731..1895865 + 135 WP_283397420.1 hypothetical protein -
MIS45_RS09245 (MIS45_09245) 1895858..1897486 + 1629 WP_249450316.1 site-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-87)

Antitoxin

Protein of unknown function DUF5397

(2-62)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.83 Da        Isoelectric Point: 5.6024

>T235959 WP_249450314.1 NZ_CP092361:1894341-1894619 [Wielerella bovis]
MYAISFDLVVSDTQNAHPKGVSQAYQDIGATLHQYGFERVQGSLYINDNEDMANLFSAIQALKNLAWFPTSVRDIRAFRI
EQWSDFTKFVKT

Download         Length: 279 bp

>T235959 NZ_LR134515:c2099891-2099463 [Actinobacillus pleuropneumoniae]
ATGTTTCAATATCTTTTTGATACCAACATCATTTCCGAGCTTTATAAGCTAGGAAGCAATAGAATGGATACCAATGTACG
ACAATGGTTAGCAACGATTAAACCGAGTCAGACGAATATTAGCTGTATCACGCTTTCCGAAATAAAAACGGGGATTTTAC
TCAAAGCTCGTAAAGATCCTATTCAAGCCGAGCGGTTAAATCATTGGTTTACCCATAATGTATTAAGCGTTTATCAAGCT
AAATCCTTTTCTATAAATAATGAAATTGCGTTACTGGCTTCTGAATACCACATTCCAAATAAAATGGATTTAAACGATGC
TTATATTGCCGCAACCGCTAAATATCATAATTTAGTGCTTGTTACTCGTAATTTGAAAGACTTCAACCGTTGCGATATAC
GTTTATTTAATCCTTTCGAACCGAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 6946.80 Da        Isoelectric Point: 4.1920

>AT235959 WP_249450313.1 NZ_CP092361:1894146-1894337 [Wielerella bovis]
MINQQNIPTGEVRTFGTFGVPYLVGKAEQELPNGDILVGIELLESGEHEQYPLSHLLQDPKAN

Download         Length: 192 bp

>AT235959 NZ_LR134515:c2100178-2099891 [Actinobacillus pleuropneumoniae]
ATGCCAATTACTATTACCTCTCGAGAATTTAATCAACACGCCAGTAAAGTGCTGAAAATGGCAGAAAAAGAACCGGTTTT
TATCACTAAATGGGGAAAAATTGTCAGCGTTGTCTCCAATTATGTTGATTACAAACAGCACACAACGGTTGAGCCTAGCT
TTGAAGAACTATTTGCCTCATCTACGGATGAATCGGTTAGCGATGAGTTTTGGCAAGATTTTGAACAGACATTAACAAAA
ATTCGCAAAAGTAATAAATCCGAACAAATAGATTTTGGAGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References