Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1618489..1619120 Replicon chromosome
Accession NZ_CP092361
Organism Wielerella bovis strain CCUG 44465

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MIS45_RS07895 Protein ID WP_249450127.1
Coordinates 1618728..1619120 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MIS45_RS07890 Protein ID WP_249450126.1
Coordinates 1618489..1618731 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIS45_RS07870 (MIS45_07870) 1613657..1615060 + 1404 WP_249450123.1 hypothetical protein -
MIS45_RS07875 (MIS45_07875) 1615712..1616410 - 699 WP_249450124.1 ATP-binding protein -
MIS45_RS07880 (MIS45_07880) 1616415..1616927 - 513 WP_249450125.1 AAA family ATPase -
MIS45_RS07885 (MIS45_07885) 1617170..1618279 - 1110 WP_249451360.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
MIS45_RS07890 (MIS45_07890) 1618489..1618731 + 243 WP_249450126.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MIS45_RS07895 (MIS45_07895) 1618728..1619120 + 393 WP_249450127.1 type II toxin-antitoxin system VapC family toxin Toxin
MIS45_RS07900 (MIS45_07900) 1619201..1619749 - 549 WP_249450128.1 NAD(P)H-dependent oxidoreductase -
MIS45_RS07905 (MIS45_07905) 1620031..1620903 - 873 WP_249450129.1 aldo/keto reductase -
MIS45_RS07910 (MIS45_07910) 1621005..1621880 + 876 WP_249450130.1 LysR family transcriptional regulator -
MIS45_RS07915 (MIS45_07915) 1621970..1622881 - 912 WP_249450131.1 type 1 glutamine amidotransferase domain-containing protein -
MIS45_RS07920 (MIS45_07920) 1622995..1623912 + 918 WP_249450132.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14786.02 Da        Isoelectric Point: 9.4026

>T235958 WP_249450127.1 NZ_CP092361:1618728-1619120 [Wielerella bovis]
MKYLLDTNIIIAFQKQHQGLLAQMKKHSVNDFALSNIVLFELAFGAYNSQKVDENLHKLSQLRFPTLTFNSQDAYHAGKI
RANLQKQGTPIGAYDTLIAGQAIAQNLILITHNIKEFERVEGLRSENWLM

Download         Length: 393 bp

>T235958 NZ_LR134515:2002591-2002989 [Actinobacillus pleuropneumoniae]
ATGCTGGCTTATATGCTTGATACTAATATTGCGATTTATGTGATTAAACGCAGACCTATTGAAGTGCTGGATAAGTTTAA
TTTAAATTCTACTCGTCTTTGTGTAAGTAGTATCACTGCAGCGGAGTTGTATTATGGTGCAGAGAAAAGCCAGTTTCCGG
AACGAAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGCGGCTACTCACTTT
GGCAATATTAAAGCACATTTATCTAAGCAAGGTAAGATCATTGGCGAGAACGATATTCATATTGCCGCACATGCAAGAAG
TGAAGGACTCGTATTAGTGACCAATAACTTGCGTGCATTTGAACGTGTGGAAGGATTGCGATTAGATAATTGGGTATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.66 Da        Isoelectric Point: 4.2696

>AT235958 WP_249450126.1 NZ_CP092361:1618489-1618731 [Wielerella bovis]
MTTAKLFWTGNSQAVRLPKEFRFEGKEVRIFKHGNQVIIEPIADDWGWVNELEPFDDTMEQAILELKNDVPQERDWSVFE

Download         Length: 243 bp

>AT235958 NZ_LR134515:2002361-2002591 [Actinobacillus pleuropneumoniae]
ATGGAAGCATCGGTATTTATGACAAACCGTAGTCAGGCGGTACGATTACCTGCAGAAGTGCGTTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTGGTAGGCAATGAACGTATTTTGGCTCCAATTAACCAAAGTTGGGATAGCTTCTTTCTGAGTT
CGGCAACGGTAAGCGATGATTTCATGACAGAGCGTGAAATCAGCATTCAGCCCGAACGTGAGGGACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References