Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 988391..988916 Replicon chromosome
Accession NZ_CP092361
Organism Wielerella bovis strain CCUG 44465

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MIS45_RS04895 Protein ID WP_249451209.1
Coordinates 988650..988916 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MIS45_RS04890 Protein ID WP_249443568.1
Coordinates 988391..988663 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIS45_RS04875 (MIS45_04875) 985941..986549 - 609 WP_249451206.1 lytic transglycosylase domain-containing protein -
MIS45_RS04880 (MIS45_04880) 986743..987339 + 597 WP_249451207.1 hypothetical protein -
MIS45_RS04885 (MIS45_04885) 987406..988305 + 900 WP_249451208.1 aldo/keto reductase -
MIS45_RS04890 (MIS45_04890) 988391..988663 + 273 WP_249443568.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MIS45_RS04895 (MIS45_04895) 988650..988916 + 267 WP_249451209.1 type II toxin-antitoxin system YafQ family toxin Toxin
MIS45_RS04900 (MIS45_04900) 988970..989434 + 465 WP_249451210.1 hypothetical protein -
MIS45_RS04905 (MIS45_04905) 989510..990109 + 600 WP_249451211.1 hypothetical protein -
MIS45_RS04910 (MIS45_04910) 990175..991245 + 1071 WP_249451212.1 3-isopropylmalate dehydrogenase -
MIS45_RS04915 (MIS45_04915) 991977..993206 + 1230 WP_249451213.1 sodium/glutamate symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10194.80 Da        Isoelectric Point: 6.8491

>T235957 WP_249451209.1 NZ_CP092361:988650-988916 [Wielerella bovis]
MKKIDYTNQFKRDAKKHFLALATAQWTEVMYCLINDLPVPIQYRDHALTGNLCDLRDCHIQLDLVLFYAKNDDTITLVRL
GSHSELGL

Download         Length: 267 bp

>T235957 NZ_LR134515:c1788257-1787790 [Actinobacillus pleuropneumoniae]
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGAAAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGTGCCTTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGTTCGGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAACCCGCAAGCAAAAC
AATTTTATTTAAAGTATGGTTTTTCATGTTCACCCATTGATGAGATGGTATTAATGTTAAAACTCTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10277.59 Da        Isoelectric Point: 4.5238

>AT235957 WP_249443568.1 NZ_CP092361:988391-988663 [Wielerella bovis]
MANINIRVDDDLKKQSFAVIERFGMTPSQAFKMFLTQIAHTNTIPLSLDYQNINYEANPTTMQAIEDYRKGRVESCSSLD
DLMDGLNEKN

Download         Length: 273 bp

>AT235957 NZ_LR134515:c1788521-1788261 [Actinobacillus pleuropneumoniae]
ATGAGAACTGCGCCAATTAATTTACGAGCGATGCCTGATCAGCGTGATTTAATTGATTATGCGGCAAGCATTTTAGGTAA
AACACGTTCTGACTTTATGTTAGAAACCGCCTGCCAAGCTGCCCAAAATGTGATTTTAGATCGTACCGTTTTCCAATTAA
ATGAGCAGGCTTTCGAGCAATTTAACCGATTGCTAGAACAGCCAACAGCAGATAATCCGGGGTTAGATAAACTGTTAAAT
ACCAAAGCGGTGTGGGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References