Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1003072..1003703 Replicon chromosome
Accession NZ_CP092360
Organism Wielerella bovis strain 07LB258

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MIS31_RS05325 Protein ID WP_249447532.1
Coordinates 1003072..1003464 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MIS31_RS05330 Protein ID WP_249442094.1
Coordinates 1003461..1003703 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIS31_RS05300 (MIS31_05300) 998479..999429 + 951 WP_249447529.1 nitronate monooxygenase -
MIS31_RS05305 (MIS31_05305) 999514..1000389 - 876 WP_249447530.1 LysR family transcriptional regulator -
MIS31_RS12605 1000487..1000609 + 123 WP_283397259.1 hypothetical protein -
MIS31_RS05310 (MIS31_05310) 1000632..1001075 + 444 WP_249442098.1 nuclear transport factor 2 family protein -
MIS31_RS05315 (MIS31_05315) 1001314..1002174 + 861 WP_249447531.1 alpha/beta fold hydrolase -
MIS31_RS05320 (MIS31_05320) 1002444..1002992 + 549 WP_249442096.1 NAD(P)H-dependent oxidoreductase -
MIS31_RS05325 (MIS31_05325) 1003072..1003464 - 393 WP_249447532.1 type II toxin-antitoxin system VapC family toxin Toxin
MIS31_RS05330 (MIS31_05330) 1003461..1003703 - 243 WP_249442094.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MIS31_RS05335 (MIS31_05335) 1003912..1005021 + 1110 WP_249447699.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
MIS31_RS05340 (MIS31_05340) 1005462..1006478 + 1017 WP_249447533.1 ATP-binding protein -
MIS31_RS05345 (MIS31_05345) 1006620..1007714 + 1095 WP_249447534.1 nucleoid-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14757.99 Da        Isoelectric Point: 9.3852

>T235955 WP_249447532.1 NZ_CP092360:c1003464-1003072 [Wielerella bovis]
MKYLLDTNIIIAFQKQHQGLLAQMKKHSVNDFALSNIVLFELAFGAYNSQKVDENLHKLSQLRFPTLTFNSQDAYHAGKI
RANLQKQGTPIGAYDTLIAGQAIAQNLILISHNVKEFERVEGLKFENWLV

Download         Length: 393 bp

>T235955 NZ_LR134515:1485967-1486227 [Actinobacillus pleuropneumoniae]
ATGAAGCTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACTGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9406.57 Da        Isoelectric Point: 4.3566

>AT235955 WP_249442094.1 NZ_CP092360:c1003703-1003461 [Wielerella bovis]
MTTAKLFWTGNSQAVRLPKEFRFEGKEVRISKHGNQVIIEPIADDWGWVNELEPFDNTMEQAILELKNDVPQERDWSVFE

Download         Length: 243 bp

>AT235955 NZ_LR134515:1485719-1485970 [Actinobacillus pleuropneumoniae]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACGATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACAAGAAGCAAGGGCGGAAATTGCGTACTTATGTCGTATGAGCAGTATTGTTCACTTGAAGAAACCGCCTATT
TGATGCGTTCACCCACCAATGCAAAACGGCTATTGGATAGTGTGGCGGAATTAAGACAGGGACAAGGCATTGAAAGAGAG
CTAATCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References