Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 820426..821054 Replicon chromosome
Accession NZ_CP092360
Organism Wielerella bovis strain 07LB258

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MIS31_RS04310 Protein ID WP_249447382.1
Coordinates 820653..821054 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MIS31_RS04305 Protein ID WP_249444738.1
Coordinates 820426..820650 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIS31_RS04285 (MIS31_04285) 815995..816417 + 423 WP_249447379.1 DUF3761 domain-containing protein -
MIS31_RS04290 (MIS31_04290) 816515..817042 + 528 WP_249447380.1 transposase -
MIS31_RS04295 (MIS31_04295) 817095..820058 + 2964 WP_249447692.1 DUF3418 domain-containing protein -
MIS31_RS04300 (MIS31_04300) 820116..820277 - 162 WP_249447381.1 YjzC family protein -
MIS31_RS04305 (MIS31_04305) 820426..820650 + 225 WP_249444738.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MIS31_RS04310 (MIS31_04310) 820653..821054 + 402 WP_249447382.1 tRNA(fMet)-specific endonuclease VapC Toxin
MIS31_RS04315 (MIS31_04315) 821088..822047 + 960 WP_249447383.1 hypothetical protein -
MIS31_RS04320 (MIS31_04320) 822040..822477 + 438 WP_249447384.1 Panacea domain-containing protein -
MIS31_RS04325 (MIS31_04325) 822492..822590 + 99 Protein_821 DNA-formamidopyrimidine glycosylase family protein -
MIS31_RS04330 (MIS31_04330) 822664..823785 - 1122 WP_249447385.1 hypothetical protein -
MIS31_RS04335 (MIS31_04335) 823906..824307 - 402 WP_249447386.1 hypothetical protein -
MIS31_RS04340 (MIS31_04340) 824429..825247 + 819 WP_249447387.1 bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 815995..827141 11146


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14906.19 Da        Isoelectric Point: 7.0501

>T235954 WP_249447382.1 NZ_CP092360:820653-821054 [Wielerella bovis]
MLRYMLDTNICIYTIKNNPAIVREKFQQHQHHLCISSIVLSELLYGAEKSDTPTKSLALIEGLAARLEVLDFDENAAAHS
AEIRAELAKKGTPIGHYDVLIAGHARSRGLVLVSNNLREFERVGGLRLENWLL

Download         Length: 402 bp

>T235954 NZ_LR134515:1485719-1485970 [Actinobacillus pleuropneumoniae]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACGATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACAAGAAGCAAGGGCGGAAATTGCGTACTTATGTCGTATGAGCAGTATTGTTCACTTGAAGAAACCGCCTATT
TGATGCGTTCACCCACCAATGCAAAACGGCTATTGGATAGTGTGGCGGAATTAAGACAGGGACAAGGCATTGAAAGAGAG
CTAATCGAATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8464.60 Da        Isoelectric Point: 4.6321

>AT235954 WP_249444738.1 NZ_CP092360:820426-820650 [Wielerella bovis]
MTQATLFKSNQTQAVRLPKAVAFPDGVKKVEVVVLGQTRLLTPSENLWDDWFAQLPQVDFPDREPTFQAERESF

Download         Length: 225 bp

>AT235954 NZ_LR134515:1485967-1486227 [Actinobacillus pleuropneumoniae]
ATGAAGCTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACTGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References