Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1647143..1647774 Replicon chromosome
Accession NZ_CP092359
Organism Wielerella bovis strain 08LB461

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MIS33_RS08150 Protein ID WP_249447532.1
Coordinates 1647382..1647774 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MIS33_RS08145 Protein ID WP_249442094.1
Coordinates 1647143..1647385 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIS33_RS08130 (MIS33_08130) 1643132..1644226 - 1095 WP_249447534.1 nucleoid-associated protein -
MIS33_RS08135 (MIS33_08135) 1644368..1645384 - 1017 WP_249447533.1 ATP-binding protein -
MIS33_RS08140 (MIS33_08140) 1645825..1646934 - 1110 WP_249447699.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
MIS33_RS08145 (MIS33_08145) 1647143..1647385 + 243 WP_249442094.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MIS33_RS08150 (MIS33_08150) 1647382..1647774 + 393 WP_249447532.1 type II toxin-antitoxin system VapC family toxin Toxin
MIS33_RS08155 (MIS33_08155) 1647854..1648402 - 549 WP_249442096.1 NAD(P)H-dependent oxidoreductase -
MIS33_RS08160 (MIS33_08160) 1648672..1649532 - 861 WP_249447531.1 alpha/beta fold hydrolase -
MIS33_RS08165 (MIS33_08165) 1649771..1650214 - 444 WP_249442098.1 nuclear transport factor 2 family protein -
MIS33_RS11715 1650237..1650359 - 123 WP_283397259.1 hypothetical protein -
MIS33_RS08170 (MIS33_08170) 1650457..1651332 + 876 WP_249447530.1 LysR family transcriptional regulator -
MIS33_RS08175 (MIS33_08175) 1651417..1652367 - 951 WP_249447529.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14757.99 Da        Isoelectric Point: 9.3852

>T235953 WP_249447532.1 NZ_CP092359:1647382-1647774 [Wielerella bovis]
MKYLLDTNIIIAFQKQHQGLLAQMKKHSVNDFALSNIVLFELAFGAYNSQKVDENLHKLSQLRFPTLTFNSQDAYHAGKI
RANLQKQGTPIGAYDTLIAGQAIAQNLILISHNVKEFERVEGLKFENWLV

Download         Length: 393 bp

>T235953 NZ_LR134514:c2110289-2109948 [Pasteurella multocida subsp. septica]
ATGGATATAATTTTCAAATCTCGAAAATTAGAAAAGGAATTAAACTCTGAAATCTACATTTTAAAGAGATACGGAACAGT
CTGCGGAAAAAAGATTAAGCTCGCAATGACCGCACTTAGGGCAGCGCCAAGTTTGCAGACATTTTTTCCACCATACAGCA
AGCCTTATCGTTGCCACGAACTTTTAGGTGACCGCAAGGGGCAAATAAGCATAGATGCACAACACCCCTATAGAGTCTTG
TTTGAAGCAAATCATAATCCGTTGCCGACCCTTGATGCAGGTGGGCTAGATTGGTCAAAAGTTACATCTATTCGGATCTT
ATCAATAACAGATACACATTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9406.57 Da        Isoelectric Point: 4.3566

>AT235953 WP_249442094.1 NZ_CP092359:1647143-1647385 [Wielerella bovis]
MTTAKLFWTGNSQAVRLPKEFRFEGKEVRISKHGNQVIIEPIADDWGWVNELEPFDNTMEQAILELKNDVPQERDWSVFE

Download         Length: 243 bp

>AT235953 NZ_LR134514:c2109935-2108850 [Pasteurella multocida subsp. septica]
ATGAGCGAAAATCAATACTACCCTGACTATGCAGTTCTGCCTGGTGAAGTGTTGGAATTTGAGCTAGATGGTTTAGAAAT
AAGCCAAAAAGAACTCAGCAATAAAACCGGCATTTCTACCAAGCACATTAGCAATATTATCAATGGCAAATCTCCGATTA
CACCTGAAACAGCAATTGCGCTCGAGCGAGTGTTGGGTAAGCCTGCGCGTTATTGGCTAAACTTGGAAACTCTATATCAA
GAGGCACTAGCTCGTATTGCAGATAAAAAAGAGCTAGAACGACATGCAGAATGGGTAAAACAGTTCCCAAATTATATTCT
GCAAAAATTAGGTTTTACCCAAAAACACACTGATATTTCAAGTAAAGTTGATACTTTGCTGCGTTTCTTTGGCGTGGCAA
GTCCTGCTGATTACGAAACTGTTTGGGGACAAATTGGTGTTCAATACCGGCAAGATAAGCGCACTACAATCTGTCAGCAC
AGTAGCTCTGCTTGGTTAAGAGCGGGGGAGATTAAGGCGAGTGAAATAATATGTCAGCCTTACTCAGAGTCAGGTTTTAA
GCAAGCGCTAGAAAAAATTAAAGCGCTCACTAAAGAAACAGAACCAAGTCATTTCATACCTGAACTCATCAATATTTGTG
CAAGTGTTGGTGTAGCTGTTGTATTTGTACCTTGCTTTCCTAACACAGGGATTAGTGGAGCAACTCGTTGGCTGTCATCG
GATAAAGCTGTAATTCAGTTGAGTTTGCGCTATAAAACGAACGATCATTTATGGTTTACTTTCTTTCATGAAGCAGGACA
TATTTTATTGCACGGCAAAAAAACACTACATTTGGAATTTAATAGTAAGACAGTTCTTGCTGATGAAGAGACTGAAGCGA
ATGATTTTGCCCAAAAGTATTTAATTCCTCGACCTATATGGCGGAATCTAATTCAAAAAGTAGCTGTTACCGAGCAGCAT
ATCCGAGCTGCTGCTGAAGAAATCGGCATTGCCGAGGGTATTATTGTCGGACAGTTACAGCACTATAAAAAATTACGCTA
TGATCAGCTTAATCATTTAAAAGTACGTTACACTTGGCAGCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References