Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 974696..975277 Replicon chromosome
Accession NZ_CP092359
Organism Wielerella bovis strain 08LB461

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MIS33_RS04880 Protein ID WP_249446465.1
Coordinates 974948..975277 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MIS33_RS04875 Protein ID WP_249446466.1
Coordinates 974696..974941 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIS33_RS04860 (MIS33_04860) 970692..973358 + 2667 WP_249446469.1 aminopeptidase N -
MIS33_RS04865 (MIS33_04865) 973431..973985 - 555 WP_249446468.1 hypothetical protein -
MIS33_RS04870 (MIS33_04870) 974108..974494 + 387 WP_249446467.1 helix-turn-helix transcriptional regulator -
MIS33_RS04875 (MIS33_04875) 974696..974941 + 246 WP_249446466.1 antitoxin Antitoxin
MIS33_RS04880 (MIS33_04880) 974948..975277 + 330 WP_249446465.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MIS33_RS04885 (MIS33_04885) 975722..977170 + 1449 WP_249446464.1 metalloprotease TldD -
MIS33_RS04890 (MIS33_04890) 977629..978642 - 1014 WP_249446463.1 CAP domain-containing protein -
MIS33_RS04895 (MIS33_04895) 978781..980214 - 1434 WP_249446462.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-107)

Antitoxin

Antitoxin PemI-like

(4-81)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12142.03 Da        Isoelectric Point: 10.1784

>T235952 WP_249446465.1 NZ_CP092359:974948-975277 [Wielerella bovis]
MERGDIFLVNLDPTTGHEQQGTRPVLIISPKAFNALTQVPIVLPITTKSQFARTQGFAVHLDERTKTQGIVRTDQSRALD
IQARNGRKLETLPIDLMNEVLAKMATFLS

Download         Length: 330 bp

>T235952 NZ_LR134514:1813852-1814178 [Pasteurella multocida subsp. septica]
ATGGACAGAGTCCGATTTAATCTTACGGAAGATAGCTTCCAAGACAAGTATCTGTATGAGTATTTTTTATATGGAAGTAA
GCATAAAAATATTCCAAGTGATATAGAAAATACGCTAGCGCATAAATTAGATATGTTAGATAGCGCAAATACTTTGAGCG
ATTTGCGAAGTCCACCAGGTAATAAATTGGAAAAATTGGAGCCTAAAACGAGTGGGCTATATTCTATCAGAGTGAATGTG
AAATATCGTTTAATATTTAAATATAAAGAAAGTAATTTTCCAAAAATAACAGAGTTGAGATTAGATAAACATCAATATAG
ATTATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8921.22 Da        Isoelectric Point: 4.9189

>AT235952 WP_249446466.1 NZ_CP092359:974696-974941 [Wielerella bovis]
MYTVSLRKVGGSTMLAIPPALLQSLDLGKQVHLHTENGRLIIEPARPQYTLAELLAQCDPNAPRDVESQTWLDAPAVGQE
W

Download         Length: 246 bp

>AT235952 NZ_LR134514:1814314-1814640 [Pasteurella multocida subsp. septica]
ATGAGTAGAGTACAAAGAAAGCCATCAACAGTGGGTGATATTTTATTAGATGAATATTTAGTTCCACTAAATTTGAAAAT
TGCAGATTTAGCTACAATGTTAGATGTTCATCGTAATACAGCGAGTGCACTCGTTAATAATAATACTAAATTGTCTTTAG
AAATGGCACTGAAACTAGCAAAACTATTTAATACAAGTCCTGAGTTTTGGTTAAATTTACAAATGAAATTAGACTTATGG
GAAATTGAAAACAATGCTAGGTTTCAAGAAAGTTTAAAGAAAATTTCGTCTATTGATCAGCATAATCTGTTAGAAAAAAT
CGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References