Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 773721..774349 Replicon chromosome
Accession NZ_CP092359
Organism Wielerella bovis strain 08LB461

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MIS33_RS03945 Protein ID WP_249447382.1
Coordinates 773948..774349 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MIS33_RS03940 Protein ID WP_249444738.1
Coordinates 773721..773945 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIS33_RS03920 (MIS33_03920) 769181..769603 + 423 WP_249447379.1 DUF3761 domain-containing protein -
MIS33_RS03925 (MIS33_03925) 769701..770228 + 528 WP_249447380.1 transposase -
MIS33_RS03930 (MIS33_03930) 770390..773353 + 2964 WP_249447692.1 DUF3418 domain-containing protein -
MIS33_RS03935 (MIS33_03935) 773411..773572 - 162 WP_249447381.1 YjzC family protein -
MIS33_RS03940 (MIS33_03940) 773721..773945 + 225 WP_249444738.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MIS33_RS03945 (MIS33_03945) 773948..774349 + 402 WP_249447382.1 tRNA(fMet)-specific endonuclease VapC Toxin
MIS33_RS03950 (MIS33_03950) 774383..775342 + 960 WP_249447383.1 hypothetical protein -
MIS33_RS03955 (MIS33_03955) 775335..775772 + 438 WP_249447384.1 Panacea domain-containing protein -
MIS33_RS03960 (MIS33_03960) 775787..775885 + 99 Protein_747 DNA-formamidopyrimidine glycosylase family protein -
MIS33_RS03965 (MIS33_03965) 775959..777080 - 1122 WP_249447385.1 hypothetical protein -
MIS33_RS03970 (MIS33_03970) 777201..777602 - 402 WP_249447386.1 hypothetical protein -
MIS33_RS03975 (MIS33_03975) 777724..778542 + 819 WP_249447387.1 bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 769181..780435 11254


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14906.19 Da        Isoelectric Point: 7.0501

>T235951 WP_249447382.1 NZ_CP092359:773948-774349 [Wielerella bovis]
MLRYMLDTNICIYTIKNNPAIVREKFQQHQHHLCISSIVLSELLYGAEKSDTPTKSLALIEGLAARLEVLDFDENAAAHS
AEIRAELAKKGTPIGHYDVLIAGHARSRGLVLVSNNLREFERVGGLRLENWLL

Download         Length: 402 bp

>T235951 NZ_LR134512:c238327-237992 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGGGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8464.60 Da        Isoelectric Point: 4.6321

>AT235951 WP_249444738.1 NZ_CP092359:773721-773945 [Wielerella bovis]
MTQATLFKSNQTQAVRLPKAVAFPDGVKKVEVVVLGQTRLLTPSENLWDDWFAQLPQVDFPDREPTFQAERESF

Download         Length: 225 bp

>AT235951 NZ_LR134512:c238604-238317 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References