Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1632102..1632733 Replicon chromosome
Accession NZ_CP092358
Organism Wielerella bovis strain 09LB414

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MIS46_RS08060 Protein ID WP_249442095.1
Coordinates 1632341..1632733 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MIS46_RS08055 Protein ID WP_249442094.1
Coordinates 1632102..1632344 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIS46_RS08035 (MIS46_08035) 1628091..1629185 - 1095 WP_249442091.1 nucleoid-associated protein -
MIS46_RS08040 (MIS46_08040) 1629327..1630343 - 1017 WP_249442092.1 ATP-binding protein -
MIS46_RS08045 (MIS46_08045) 1630359..1630541 - 183 WP_249442093.1 hypothetical protein -
MIS46_RS08050 (MIS46_08050) 1630784..1631893 - 1110 WP_249443825.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
MIS46_RS08055 (MIS46_08055) 1632102..1632344 + 243 WP_249442094.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MIS46_RS08060 (MIS46_08060) 1632341..1632733 + 393 WP_249442095.1 type II toxin-antitoxin system VapC family toxin Toxin
MIS46_RS08065 (MIS46_08065) 1632813..1633361 - 549 WP_249442096.1 NAD(P)H-dependent oxidoreductase -
MIS46_RS08070 (MIS46_08070) 1633631..1634521 - 891 WP_249442097.1 alpha/beta fold hydrolase -
MIS46_RS08075 (MIS46_08075) 1634731..1635174 - 444 WP_249442098.1 nuclear transport factor 2 family protein -
MIS46_RS11465 1635197..1635319 - 123 WP_283397259.1 hypothetical protein -
MIS46_RS08080 (MIS46_08080) 1635417..1636292 + 876 WP_249442099.1 LysR family transcriptional regulator -
MIS46_RS08085 (MIS46_08085) 1636382..1637293 - 912 WP_249442100.1 type 1 glutamine amidotransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14772.01 Da        Isoelectric Point: 9.3852

>T235950 WP_249442095.1 NZ_CP092358:1632341-1632733 [Wielerella bovis]
MKYLLDTNIIIAFQKQHQGLLAQMKKHSVNDFALSNIVLFELAFGAYNSQKVDENLHKLSQLRFPTLTFNSQDAYHAGKI
RANLQKQGTPIGAYDTLIAGQAIAQNLILISHNVKEFERIEGLKFENWLV

Download         Length: 393 bp

>T235950 NZ_LR134509:1372372-1372647 [Helicobacter pullorum]
ATGAGAAAAATTGACATTAAAAACACTTTCAAAAAAGATTATAGACAAGTCTTGAAACAAGGTTGGAGTGAAAATGCTAT
TGATGAAGTGATTAAACAACTTGCAAACGATGATATTTTAAATCCACAATTAAAACCGCATCCATTAGGTGGAGATTATA
AAAATTATATGGAATGCCATATTTTTAGCGATTTGATAATAATATATCAAAGAGATAAAGAAATTTTAAGTCTTTATCGC
ATAGGAAGACACCAAGACTTATTTAAAAGCTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9406.57 Da        Isoelectric Point: 4.3566

>AT235950 WP_249442094.1 NZ_CP092358:1632102-1632344 [Wielerella bovis]
MTTAKLFWTGNSQAVRLPKEFRFEGKEVRISKHGNQVIIEPIADDWGWVNELEPFDNTMEQAILELKNDVPQERDWSVFE

Download         Length: 243 bp

>AT235950 NZ_LR134509:1372091-1372372 [Helicobacter pullorum]
ATGTTTGATTATGCTAAATATGAAAATGCAACACAAAAAGAAATAATACATGCTTTAAATCTAACACAAAGAAAATCAGA
AAAGTTAAACCAGCAATTAAAAGAGAATAGAGAGATTTTTAAATTTTTGCAAAAAAAATTAAAAGAATCTTTTAGTTCCA
AAAAAAACAAAAAAAATAATATTCCAAATAGTAAAACAATTAATGTTTTAAACAATAATACAAGTATAGGGGTTTTTAAT
GATTTTGATGAAGCTAAAAAAGCCTTAATGAGTGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References